Now showing items 3-7 of 7

    • Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations 

      Huang-Doran, Isabel; Tomlinson, Patsy; Payne, Felicity; Gast, Alexandra; Sleigh, Alison; Bottomley, William; Harris, Julie et al. (American Society for Clinical Investigation, 2016-10-05)
      Obesity-related insulin resistance is associated with fatty liver, dyslipidemia, and low plasma adiponectin. Insulin resistance due to insulin receptor (INSR) dysfunction is associated with none of these, but when due to ...
    • ³¹P magnetization transfer measurements of Pi->ATP flux in exercising human muscle 

      Sleigh, Alison; Savage, David B.; Williams, Guy B.; Porter, David; Carpenter, T. Adrian; Brindle, Kevin M.; Kemp, Graham J. (American Physiological Society, 2016)
      Fundamental criticisms have been made over the use of 31P-MRS magnetization transfer estimates of Pi->ATP flux (VPi-ATP) in human resting skeletal muscle for assessing mitochondrial function. Although the discrepancy in ...
    • Randomised controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial 

      Finucane, Francis M.; Horton, Jessica; Purslow, Lisa R.; Savage, David B.; Brage, Søren; Besson, Herve; Horton, Kenneth et al. (2009-06-19)
      Abstract Background While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity ...
    • Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using 31P magnetic resonance spectroscopy 

      Sleigh, Alison; Lupson, Victoria; Thankamony, Ajay; Dunger, David B.; Savage, David B.; Carpenter, Adrian; Kemp, Graham J. (Nature Publishing Group, 2016-01-11)
      The growing recognition of diseases associated with dysfunction of mitochondria poses an urgent need for simple measures of mitochondrial function. Assessment of the kinetics of replenishment of the phosphocreatine pool ...
    • Truncation of POC1A associated with short stature and extreme insulin resistance 

      Chen, Jian-Hua; Segni, Maria; Payne, Felicity; Huang-Doran, Isabel; Sleigh, Alison; Adams, Claire; UK10K Consortium et al. (Bioscientifica, 2015-10-01)
      We describe a female proband with primordial dwarfism, skeletal dysplasia, facial dysmorphism, extreme dyslipidaemic insulin resistance and fatty liver associated with a novel homozygous frameshift mutation in POC1A, ...