Now showing items 1-15 of 15

    • The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1and BRCA2mutation carriers 

      Spurdle, Amanda B; Antoniou, Antonis; Duffy, David L; Pandeya, Nirmala; Kelemen, Livia; Chen, Xiaoqing; Peock, Susan et al. (2004-12-16)
      Abstract Introduction The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have ...
    • The Autism-Spectrum Quotient in Siblings of People With Autism 

      Ruzich, Emily; Allison, Catherine; Smith, Paula; Ring, Howard Anton; Auyeung, Bonnie; Baron-Cohen, Simon (Wiley, 2016-06-22)
      This study measures the distribution of autistic traits, using the autism-spectrum quotient (AQ), in siblings of individuals with autism spectrum conditions (ASC). Total AQ scores, along with AQ subscales, were collected ...
    • BRCA1and BRCA2mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families 

      Antoniou, Antonis; Francine, Durocher; Smith, Paula; Simard, Jacques; Easton, Douglas Frederick (2005-12-12)
      Abstract Introduction Several genetic risk models for breast and ovarian cancer have been developed, but their applicability to specific populations has not been evaluated. We used data from French-Canadian families to ...
    • Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs 

      Benusiglio, Patrick R; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison Margaret et al. (2005-07-19)
      Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast ...
    • A comprehensive meta-analysis of common genetic variants in Autism Spectrum Conditions 

      Warrier, Varun; Chee, Vivienne; Smith, Paula; Chakrabarti, Bhismadev; Baron-Cohen, Simon (2015-08-20)
      Background: Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by difficulties in social interaction and communication alongside repetitive and stereotyped behaviours. ASC are ...
    • Correction: The overlap between autistic spectrum conditions and borderline personality disorder. 

      Dudas, Robert; Lovejoy, Chris; Cassidy, Sarah; Allison, Catherine; Smith, Paula; Baron-Cohen, Simon (2018-01-02)
    • Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females 

      Ruzich, Emily; Allison, Catherine; Smith, Paula; Watson, Peter; Auyeung, Bonnie; Ring, Howard Anton; Baron-Cohen, Simon (BioMed Central, 2015-01-14)
      The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of at least average intelligence with autism and to nonclinical ...
    • Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures 

      Stone, Jennifer; Thompson, Deborah Jane; dos, Santos Silva Isabel; Scott, Christopher; Tamimi, Rulla M; Lindstrom, Sara; Kraft, Peter et al. (American Association for Cancer Research, 2015-04-10)
      Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 ...
    • The overlap between autistic spectrum conditions and borderline personality disorder 

      Dudas, Robert; Lovejoy, Chris; Cassidy, Sarah; Allison, Catherine; Smith, Paula; Baron-Cohen, Simon
      BACKGROUND: Both people with autism spectrum conditions (ASC) and borderline personality disorder (BPD) are significantly challenged in terms of understanding and responding to emotions and in interpersonal functioning. ...
    • "Putting on My Best Normal": Social Camouflaging in Adults with Autism Spectrum Conditions. 

      Hull, Laura; Petrides, KV; Allison, Catherine; Smith, Paula; Baron-Cohen, Simon; Lai, Meng-Chuan; Mandy, William (2017-08)
    • The “Reading the Mind in the Eyes” test: Complete absence of typical sex difference in ~400 men and women with autism 

      Baron-Cohen, Simon; Bowen, Daniel C; Holt, Rosemary Jane; Allison, Catherine; Auyeung, Bonnie; Lombardo, Michael V; Smith, Paula et al. (PLoS, 2015)
      The “Reading the Mind in the Eyes” test (Eyes test) is an advanced test of theory of mind. Typical sex difference has been reported (i.e., female advantage). Individuals with autism show more difficulty than do typically ...
    • Sex and STEM occupation predict Autism-Spectrum Quotient (AQ) scores in half a million people 

      Ruzich, Emily; Allison, Catherine; Chakrabarti, Bhismadev; Smith, Paula; Musto, Henry; Ring, Howard Anton; Baron-Cohen, Simon (PLoS, 2015-10-21)
      This study assesses Autism-Spectrum Quotient (AQ) scores in a ‘big data’ sample collected through the UK Channel 4 television website, following the broadcasting of a medical education program. We examine correlations ...
    • Subgrouping siblings of people with autism: identifying the broader autism phenotype 

      Ruzich, Emily; Allison, Catherine; Smith, Paula; Watson, Peter; Auyeung, Bonnie; Ring, Howard Anton; Baron-Cohen, Simon (Wiley, 2015-09-02)
      We investigate the broader autism phenotype (BAP) in siblings of individuals with autism spectrum conditions (ASC). Autistic traits were measured in typical controls (n = 2,000), siblings (n = 496), and volunteers with ASC ...
    • Unsupervised data-driven stratification of mentalizing heterogeneity in autism 

      Lombardo, Michael V; Lai, Meng-Chuan; Auyeung, Bonnie; Holt, Rosemary J; Allison, Catherine; Smith, Paula; Chakrabarti, Bhismadev et al. (2016-10-18)
    • Unsupervised data-driven stratification of mentalizing heterogeneity in autism 

      Lombardo, Michael V; Lai, Meng-Chuan; Auyeung, Bonnie; Holt, Rosemary Jane; Allison, Catherine; Smith, Paula; Chakrabarti, Bhismadev et al. (Nature Publishing Group, 2016-10-18)
      Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a ...