Now showing items 8-14 of 14

    • IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients 

      Ferreira, Ricardo C; Simons, Henry Z; Thompson, Whitney S; Cutler, Antony John; Dopico, Xaquin Castro; Smyth, Deborah J; Mashar, Meghavi et al. (Springer, 2015-02-06)
      Aims/hypothesis Type 1 diabetes results from the autoimmune destruction of insulin-secreting pancreatic beta cells by T cells. Despite the established role of T cells in the pathogenesis of the disease, to date, with the ...
    • A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations 

      Evangelou, Marina; Smyth, Deborah J; Fortune, Mary Doris; Burren, Oliver S; Walker, Neil M; Guo, Hui; Onengut-Gumuscu, Suna et al. (Wiley, 2014-11-04)
      Pathway analysis can complement point-wise single nucleotide polymorphism (SNP) analysis in exploring genomewide association study (GWAS) data to identify specific disease-associated genes that can be candidate causal ...
    • Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes 

      Yang, Jennie HM; Cutler, Antony John; Ferreira, Ricardo C; Reading, James L; Cooper, Nicholas J; Wallace, Chris; Clarke, Pamela et al. (American Diabetes Association, 2015-07-29)
      Defective immune homeostasis in the balance between FOXP3+ regulatory T cells (Tregs) and effector T cells is a likely contributing factor in the loss of self-tolerance observed in type 1 diabetes (T1D). Given the importance ...
    • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial 

      Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, Linsey et al. (2016-10-11)
      BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive ...
    • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial 

      Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, Linsey et al. (Public Library of Science, 2016-10-11)
      $\textbf{Background}$ Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4$^+$ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and ...
    • A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes 

      Ferreira, Ricardo C; Guo, Hui; Coulson, Richard MR; Smyth, Deborah J; Pekalski, Marcin Lukasz; Burren, Oliver S; Cutler, Antony John et al. (American Diabetes Association, 2014-02-21)
      Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost nothing is known about events leading to this islet autoimmunity. ...
    • Widespread seasonal gene expression reveals annual differences in human immunity 

      Dopico, Xaquin Castro; Evangelou, Marina; Ferreira, Ricardo C; Guo, Hui; Pekalski, Marcin Lukasz; Smyth, Deborah J; Cooper, Nicholas et al. (NPG, 2015-05-12)
      Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding ...