Now showing items 11-12 of 12

    • A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects 

      Jervis, Sarah; Song, Honglin; Lee, Andrew John; Dicks, Ed; Harrington, Patricia; Baynes, Caroline; Manchanda, Ranjit et al. (BMJ Publishing, 2015-05-29)
      Background: Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that considers the effects of BRCA1, BRCA2 and other ...
    • Telomere structure and maintenance gene variants and risk of five cancer types 

      Karami, S; Han, Y; Pande, M; Cheng, I; Rudd, J; Pierce, BL; Nutter, EL et al. (Wiley, 2016-07-26)
      Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded ...