Now showing items 2-3 of 3

    • Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk 

      Bettens, Karolien; Brouwers, Nathalie; Engelborghs, Sebastiaan; Lambert, Jean-Charles; Rogaeva, Ekaterina; Vandenberghe, Rik; Le Bastard, Nathalie et al. (2012-01-16)
      Abstract Background We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons ...
    • Single-molecule Imaging Reveals that Small Amyloid-β1-42 Oligomers Interact with the Cellular Prion Protein (PrPC) 

      Ganzinger, Kristina A.; Narayan, Priyanka; Qamar, Seema S.; Weimann, Laura; Ranasinghe, Rohan T.; Aguzzi, Adriano; Dobson, Christopher M. et al. (Wiley, 2014-10-07)
      Oligomers of the amyloid-β peptide (Aβ) play a central role in the pathogenesis of Alzheimer’s disease and have been suggested to induce neurotoxicity by binding to a plethora of cell-surface receptors. However, the ...