Now showing items 1-19 of 19

• #### Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study ﻿

(Wiley, 2016-09-19)
Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ...
• #### Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels ﻿

(Wiley, 2016)
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are ...
• #### Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation ﻿

(Nature Publishing Group, 2016-04-07)
Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...
• #### Blood lipids and prostate cancer: a Mendelian randomization analysis ﻿

(Wiley, 2016-03-19)
Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer ...
• #### Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans. ﻿

(2017-02-02)
BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and ...
• #### Flavonoid and lignan intake and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ﻿

(Wiley, 2016)
Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between ...
• #### Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array ﻿

(Nature Publishing Group, 2016-03-10)
Background: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, ...
• #### Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types ﻿

(American Association for Cancer Research, 2016-07-17)
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest ...
• #### The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk ﻿

(2010-10-18)
Abstract Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass ...
• #### Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis ﻿

(Wiley, 2016-10-26)
Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian ...
• #### Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study. ﻿

(BioMed Central, 2016-06-14)
BACKGROUND: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, ...
• #### PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS ﻿

(BMJ Publishing Group, 2016-09-05)
Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
• #### Physical Activity and all-cause mortality across levels of general and abdominal adiposity: The European Prospective Investigation into Cancer and Nutrition Study (EPIC) ﻿

(American Society for Nutrition, 2015-01-14)
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall ...
• #### Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. ﻿

(BMJ, 2018-01-10)
Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines ...
• #### Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. ﻿

(2016-08-04)
• #### Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition ﻿

(2017-07-05)
Abstract Background Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between ...
• #### Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort ﻿

(BioMed Central, 2016-04-04)
Background: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates ...
• #### SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns. ﻿

(Oxford University Press, 2017-03)
$\textbf{MOTIVATION}$: Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped. ...
• #### Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study ﻿

(2017-07-13)
Abstract Background The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not ...