Now showing items 3-13 of 13

    • Defining KIR and HLA class I Genotypes at Highest Resolution Using High-Throughput Sequencing 

      Norman, Paul J.; Hollenbach, Jill A.; Nemat-Gorgani, Neda; Marin, Wesley M.; Norberg, Steven J.; Ashouri, Elham; Jayaraman, Jyothi et al. (Elsevier (Cell Press), 2016)
      The physiological functions of natural killer (NK) cells in human immunity and reproduction depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIR) and their HLA class I ligands: HLA-A, -B ...
    • Imputation of KIR types from SNP variation data 

      Vukcevic, Damjan; Traherne, James A.; Næss, Sigrid; Ellinghaus, Eva; Kamatani, Yoichiro; Dilthey, Alexander; Lathrop, Mark et al. (Elsevier, 2015-10-01)
      Large population studies of immune system genes are essential for uncovering their role in diseases, including autoimmune conditions. One such group of genes, encoding the killer-cell immunoglobulin-like receptors (KIRs), ...
    • A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia 

      Nakimuli, Annettee; Chazara, Olympe; Hiby, Susan E.; Farrell, Lydia; Tukwasibwe, Stephen; Jayaraman, Jyothi; Traherne, James A. et al. (National Academy of Sciences, 2015-01-05)
      In Sub-Saharan Africans, maternal mortality is unacceptably high with >400 deaths/100,000 births compared to <10/100,000 in Europeans. One third of the deaths are caused by pre-eclampsia, a syndrome arising from defective ...
    • KIR haplotypes are associated with late-onset type 1 diabetes in European–American families 

      Traherne, James A.; Jiang, Wei; Valdes, Ana Maria; Hollenbach, Jill A.; Jayaraman, Jyothi; Lane, Julie A.; Johnson, Chris et al. (Nature Publishing Group, 2015-10-22)
      Classical human leukocyte antigens (HLA) genes confer the strongest, but not the only, genetic susceptibility to type 1 diabetes. Killer cell immunoglobulin-like receptors (KIR), on natural killer (NK) cells, bind ligands ...
    • NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study 

      de Kruijf, Esther M.; Sajet, Anita; van Nes, Johanna G. H.; Putter, Hein; Smit, Vincent T. H. B. M.; Eagle, Robert A.; Jafferji, Insiya et al. (2012-01-18)
      Abstract Background Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an immune response. We examined tumor expression ...
    • Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach 

      Stevens, James; Joly, Etienne; Trowsdale, John; Butcher, Geoffrey W. (2001-06-20)
      Abstract Background Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class Ib molecule. However, its ...
    • TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst. 

      Hermann, Clemens; van Hateren, Andy; Trautwein, Nico; Neerincx, Andreas; Duriez, Patrick J.; Stevanović, Stefan; Trowsdale, John et al. (eLife, 2015-10-06)
      Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second MHC I-specific chaperone. We sought to determine whether, like ...
    • TAPBPR: a new player in the MHC class I presentation pathway 

      Hermann, Clemens; Trowsdale, John; Boyle, Louise H. (Wiley, 2015-02-26)
      In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells. A key player for ...
    • TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils 

      Radjabova, Valeria; Mastroeni, Piero; Skjødt, Karsten; Zaccone, Paola; de Bono, Bernard; Goodall, Jane C.; Chilvers, Edwin R. et al. (American Association of Immunologists, 2015-08-26)
      We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell–interacting, activating receptor on myeloid cells-1 ...
    • TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils 

      Radjabova, Valeria; Mastroeni, Piero; Skjødt, Karsten; Zaccone, Paola; de Bono, Bernard; Goodall, Jane C.; Chilvers, Edwin R. et al. (American Association of Immunologists, 2015-08-26)
      We identified a novel, evolutionarily conserved receptor encoded within the human Leukocyte Receptor Complex (LRC) and syntenic region of mouse chromosome 7, named T cell interacting, activating receptor on myeloid cells-1 ...
    • The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection 

      Brown, Damien P.; Jones, Des C.; Anderson, Katie J.; Lapaque, Nicolas; Buerki, Robin A.; Trowsdale, John; Allen, Rachel L. (2009-10-27)
      Abstract Background Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic ...