Now showing items 1-5 of 5

    • Contrasting signals of positive selection in genes involved in human skin color variation from tests based on SNP scans and resequencing 

      de Gruijter, Johanna Maria; Lao, Oscar; Vermeulen, Mark; Xue, Yali; Woodwark, Cara; Gillson, Christopher J.; Coffey, Alison J. et al. (2011-12-01)
      Abstract Background Numerous genome-wide scans conducted by genotyping previously ascertained single-nucleotide polymorphisms (SNPs) have provided candidate signatures for positive selection in various regions of the human ...
    • Expansion of the HSFY gene family in pig lineages 

      Skinner, Benjamin M.; Lachani, Kim; Sargent, Carole A.; Yang, Fengtang; Ellis, Peter; Hunt, Toby; Fu, Beiyuan et al. (BioMed Central, 2015-06-09)
      Background: Amplified gene families on sex chromosomes can harbour genes with important biological functions, especially relating to fertility. The Y-linked heat shock transcription factor (HSFY) family has become amplified ...
    • Health and population effects of rare gene knockouts in adult humans with related parents 

      Narasimhan, Vagheesh M.; Hunt, Karen A.; Mason, Dan; Baker, Christopher L.; Karczewski, Konrad J.; Barnes, Michael R.; Barnett, Anthony H. et al. (American Association for the Advancement of Science, 2016-03-03)
      Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British Pakistani-heritage adults with high parental relatedness, discovering 1111 rare-variant ...
    • The pig X and Y Chromosomes: structure, sequence, and evolution 

      Skinner, Benjamin M.; Sargent, Carole A.; Churcher, Carol; Hunt, Toby; Herrero, Javier; Loveland, Jane E.; Dunn, Matt et al. (Cold Spring Harbor Laboratory Press, 2015-11-11)
      We have generated an improved assembly and gene annotation of the pig X Chromosome, and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones from Duroc animals and incorporating information ...
    • 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care 

      Clarke, Angus J.; Cooper, David N.; Krawczak, Michael; Tyler-Smith, Chris; Wallace, Helen M.; Wilkie, Andrew O. M.; Raymond, Frances L. et al. (2012-08-02)
      Abstract This report is of a round-table discussion held in Cardiff in September 2009 for Cesagen, a research centre within the Genomics Network of the UK’s Economic and Social Research Council. The meeting was ...