Now showing items 1-9 of 9

    • Contrasting signals of positive selection in genes involved in human skin color variation from tests based on SNP scans and resequencing 

      de Gruijter, Johanna Maria; Lao, Oscar; Vermeulen, Mark; Xue, Yali; Woodwark, Cara; Gillson, Christopher J.; Coffey, Alison J. et al. (2011-12-01)
      Abstract Background Numerous genome-wide scans conducted by genotyping previously ascertained single-nucleotide polymorphisms (SNPs) have provided candidate signatures for positive selection in various regions of the human ...
    • Expansion of the HSFY gene family in pig lineages 

      Skinner, Benjamin M; Lachani, Kim; Sargent, Carole A; Yang, Fengtang; Ellis, Peter; Hunt, Toby; Fu, Beiyuan et al. (2015-06-09)
      Abstract Background Amplified gene families on sex chromosomes can harbour genes with important biological functions, especially relating to fertility. The Y-linked heat shock ...
    • Expansion of the HSFY gene family in pig lineages 

      Skinner, Benjamin Matthew; Lachani, Kim; Sargent, Carole Anne; Yang, Fengtang; Ellis, Peter; Hunt, Toby; Fu, Beiyuan et al. (2015-06-09)
    • Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data. 

      Hu, Min; Ayub, Qasim; Guerra-Assunção, José Afonso; Long, Quan; Ning, Zemin; Huang, Ni; Romero, Irene Gallego et al. (2012-05)
    • Genomic analyses inform on migration events during the peopling of Eurasia. 

      Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Jon Anders; Mitt, Mario; Clemente, Florian et al. (2016-10)
    • Health and population effects of rare gene knockouts in adult humans with related parents 

      Narasimhan, Vagheesh M; Hunt, Karen A; Mason, Dan; Baker, Christopher L; Karczewski, Konrad J; Barnes, Michael R; Barnett, Anthony H et al. (American Association for the Advancement of Science, 2016-03-03)
      Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British Pakistani-heritage adults with high parental relatedness, discovering 1111 rare-variant ...
    • The pig X and Y Chromosomes: structure, sequence, and evolution 

      Skinner, Benjamin Matthew; Sargent, Carole Anne; Churcher, Carol; Hunt, Toby; Herrero, Javier; Loveland, Jane E; Dunn, Matt et al. (2015-11-11)
    • 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care 

      Clarke, Angus J; Cooper, David N; Krawczak, Michael; Tyler-Smith, Chris; Wallace, Helen M; Wilkie, Andrew OM; Raymond, Frances Lucy et al. (2012-08-02)
      Abstract This report is of a round-table discussion held in Cardiff in September 2009 for Cesagen, a research centre within the Genomics Network of the UK’s Economic and Social Research Council. The meeting was ...
    • Using ancestry-informative markers to identify fine structure across 15 populations of European origin. 

      Huckins, Laura M; Boraska, Vesna; Franklin, Christopher S; Floyd, James AB; Southam, Lorraine; GCAN,; WTCCC3, et al. (2014-10)