Now showing items 4-5 of 5

    • The molecular basis for stability of heterochromatin-mediated silencing in mammals 

      Hiragami-Hamada, Kyoko; Xie, Sheila Q.; Saveliev, Alexander; Uribe-Lewis, Santiago; Pombo, Ana; Festenstein, Richard J. (2009-11-04)
      Abstract The archetypal epigenetic phenomenon of position effect variegation (PEV) in Drosophila occurs when a gene is brought abnormally close to heterochromatin, resulting in stochastic silencing of the affected gene in ...
    • Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions 

      Stojic, Lovorka; Niemczyk, Malwina; Orjalo, Arturo; Ito, Yoko; Ruijter, Anna Elisabeth Maria; Uribe-Lewis, Santiago; Joseph, Nimesh et al. (Nature Publishing Group, 2016-02-02)
      Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is lacking. To address this, we used multiple small ...