Now showing items 4-9 of 9

    • Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARgamma-defective (P465L) mice 

      Gotz, Alexander A.; Vidal-Puig, Antonio; Rodel, Heiko G.; Hrabe de Angelis, Martin; Stoeger, Tobias (2011-09-20)
      Abstract Background The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ...
    • Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice 

      Sanghez, Valentina; Cubuk, Cankut; Sebastian-Leon, Patricia; Carobbio, Stefania; Dopazo, Joaquin; Vidal-Puig, Antonio; Bartolomucci, Alessandro (Taylor & Francis, 2016-03-07)
      Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like ...
    • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis 

      Charalambous, Marika; Teixeira Da Rocha, Simao; Radford, Elizabeth Jane; Medina-Gomez, Gema; Curran, Scott; Pinnock, Scarlett B.; Ferrón, Sacri R. et al. (PNAS, 2014-10-27)
      Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and obesity, as well as progressive liver dysfunction. Recent animal studies have underscored the importance of hepatic growth hormone (GH) ...
    • Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass 

      Vivas, Yurena; Martinez-Garcia, Cristina; Izquierdo, Adriana; Garcia-Garcia, Francisco; Callejas, Sergio; Velasco, Ismael; Campbell, Mark et al. (2011-12-30)
      Abstract Background The progression towards type 2 diabetes depends on the allostatic response of pancreatic beta cells to synthesise and secrete enough insulin to compensate for insulin resistance. The endocrine pancreas ...
    • Increased Dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function 

      Barbarroja, Nuria; Rodriguez-Cuenca, Sergio; Nygren, Heli; Camargo, Antonio; Pirraco, Ana; Relat, Joana; Cuadrado, Irene et al. (American Diabetes Association, 2014-10-28)
      Adipose tissue dysfunction is an important determinant of obesity-associated lipid induced metabolic complications. Ceramides are well known mediators of lipid induced insulin resistance in peripheral organs such as ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J.; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Sam; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...