Now showing items 4-13 of 13

    • Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARgamma-defective (P465L) mice 

      Gotz, Alexander A; Vidal-Puig, Antonio; Rodel, Heiko G; Hrabe, de Angelis Martin; Stoeger, Tobias (2011-09-20)
      Abstract Background The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ...
    • Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice 

      Sanghez, Valentina; Cubuk, Cankut; Sebastian-Leon, Patricia; Carobbio, Stefania; Dopazo, Joaquin; Vidal-Puig, Antonio; Bartolomucci, Alessandro (Taylor & Francis, 2016-03-07)
      Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like ...
    • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis 

      Charalambous, Marika; Teixeira, Da Rocha Simao; Radford, Elizabeth Jane; Medina-Gomez, Gema; Curran, Scott; Pinnock, Scarlett B; Ferrón, Sacri R et al. (PNAS, 2014-10-27)
      Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and obesity, as well as progressive liver dysfunction. Recent animal studies have underscored the importance of hepatic growth hormone (GH) ...
    • Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass 

      Vivas, Yurena; Martinez-Garcia, Cristina; Izquierdo, Adriana; Garcia-Garcia, Francisco; Callejas, Sergio; Velasco, Ismael; Campbell, Mark et al. (2011-12-30)
      Abstract Background The progression towards type 2 diabetes depends on the allostatic response of pancreatic beta cells to synthesise and secrete enough insulin to compensate for insulin resistance. The endocrine pancreas ...
    • Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance 

      Martínez-Sánchez, N; Seoane-Collazo, P; Contreras, C; Varela, L; Villarroya, J; Rial-Pensado, E; Buqué, X et al. (Elsevier, 2017-07-05)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic ...
    • Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. 

      Hall, Zoe; Bond, Nicholas J; Ashmore, Tom; Sanders, Francis; Ament, Zsuzsanna; Wang, Xinzhu; Murray, Andrew James et al. (Wiley, 2017-04)
      Non-alcoholic fatty liver disease (NAFLD) can progress from 'simple steatosis' (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis and cancer. Currently the driver for this progression is not fully understood; in ...
    • No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men. 

      Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R; Virtue, Samuel; Watson, Laura Pe; Murgatroyd, Peter R; Ambler, Graeme K et al. (American Society for Clinical Nutrition, Inc., 2017-11)
      ABSTRACT Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme ½AQ3 ...
    • Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans 

      Virtue, Samuel; Masoodi, M; Weijer, BAM de; Eijk, M van; Mok, CYL; Eiden, M; Dale, M et al. (NPG, 2015-03-24)
      BACKGROUND/OBJECTIVES: Obesity has been associated with both changes in adipose tissue lipid metabolism and inflammation. A key class of lipid-derived signalling molecules involved in inflammation are the prostaglandins. ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Samuel; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...
    • Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases 

      Rodriguez-Cuenca, Sergio; Pellegrinelli, Vanessa Florence; Campbell, M; Oresic, M; Vidal-Puig, Antonio (Elsevier, 2017-04-01)
      Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic ...