Now showing items 7-11 of 11

    • Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass 

      Vivas, Yurena; Martinez-Garcia, Cristina; Izquierdo, Adriana; Garcia-Garcia, Francisco; Callejas, Sergio; Velasco, Ismael; Campbell, Mark et al. (2011-12-30)
      Abstract Background The progression towards type 2 diabetes depends on the allostatic response of pancreatic beta cells to synthesise and secrete enough insulin to compensate for insulin resistance. The endocrine pancreas ...
    • Increased Dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function 

      Barbarroja, Nuria; Rodriguez-Cuenca, Sergio; Nygren, Heli; Camargo, Antonio; Pirraco, Ana; Relat, Joana; Cuadrado, Irene et al. (American Diabetes Association, 2014-10-28)
      Adipose tissue dysfunction is an important determinant of obesity-associated lipid induced metabolic complications. Ceramides are well known mediators of lipid induced insulin resistance in peripheral organs such as ...
    • Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. 

      Hall, Zoe; Bond, Nicholas J; Ashmore, Tom; Sanders, Francis; Ament, Zsuzsanna; Wang, Xinzhu; Murray, Andrew James et al. (Wiley, 2017-04)
      Non-alcoholic fatty liver disease (NAFLD) can progress from 'simple steatosis' (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis and cancer. Currently the driver for this progression is not fully understood; in ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J.; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Sam; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...
    • Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases 

      Rodriguez-Cuenca, Sergio; Pellegrinelli, Vanessa Florence; Campbell, M; Oresic, M; Vidal-Puig, Antonio (Elsevier, 2017-04-01)
      Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic ...