Now showing items 7-9 of 9

    • Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass 

      Vivas, Yurena; Martinez-Garcia, Cristina; Izquierdo, Adriana; Garcia-Garcia, Francisco; Callejas, Sergio; Velasco, Ismael; Campbell, Mark et al. (2011-12-30)
      Abstract Background The progression towards type 2 diabetes depends on the allostatic response of pancreatic beta cells to synthesise and secrete enough insulin to compensate for insulin resistance. The endocrine pancreas ...
    • Increased Dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function 

      Barbarroja, Nuria; Rodriguez-Cuenca, Sergio; Nygren, Heli; Camargo, Antonio; Pirraco, Ana; Relat, Joana; Cuadrado, Irene et al. (American Diabetes Association, 2014-10-28)
      Adipose tissue dysfunction is an important determinant of obesity-associated lipid induced metabolic complications. Ceramides are well known mediators of lipid induced insulin resistance in peripheral organs such as ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J.; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Sam; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...