Now showing items 8-12 of 12

    • Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance 

      Martínez-Sánchez, N; Seoane-Collazo, P; Contreras, C; Varela, L; Villarroya, J; Rial-Pensado, E; Buqué, X et al. (Elsevier, 2017-07-05)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic ...
    • Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. 

      Hall, Zoe; Bond, Nicholas J; Ashmore, Tom; Sanders, Francis; Ament, Zsuzsanna; Wang, Xinzhu; Murray, Andrew James et al. (Wiley, 2017-04)
      Non-alcoholic fatty liver disease (NAFLD) can progress from 'simple steatosis' (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis and cancer. Currently the driver for this progression is not fully understood; in ...
    • Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans 

      Virtue, Samuel; Masoodi, M; Weijer, BAM de; Eijk, M van; Mok, CYL; Eiden, M; Dale, M et al. (2015-03-24)
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Samuel; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (2015-11-20)
    • Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases 

      Rodriguez-Cuenca, Sergio; Pellegrinelli, Vanessa Florence; Campbell, M; Oresic, M; Vidal-Puig, Antonio (Elsevier, 2017-04-01)
      Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic ...