Now showing items 9-11 of 11

    • Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. 

      Hall, Zoe; Bond, Nicholas J; Ashmore, Tom; Sanders, Francis; Ament, Zsuzsanna; Wang, Xinzhu; Murray, Andrew James et al. (Wiley, 2017-04)
      Non-alcoholic fatty liver disease (NAFLD) can progress from 'simple steatosis' (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis and cancer. Currently the driver for this progression is not fully understood; in ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J.; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Sam; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...
    • Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases 

      Rodriguez-Cuenca, Sergio; Pellegrinelli, Vanessa Florence; Campbell, M; Oresic, M; Vidal-Puig, Antonio (Elsevier, 2017-04-01)
      Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic ...