Now showing items 10-13 of 13

    • No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men. 

      Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R; Virtue, Samuel; Watson, Laura Pe; Murgatroyd, Peter R; Ambler, Graeme K et al. (American Society for Clinical Nutrition, Inc., 2017-11)
      ABSTRACT Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme ½AQ3 ...
    • Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans 

      Virtue, Samuel; Masoodi, M; Weijer, BAM de; Eijk, M van; Mok, CYL; Eiden, M; Dale, M et al. (NPG, 2015-03-24)
      BACKGROUND/OBJECTIVES: Obesity has been associated with both changes in adipose tissue lipid metabolism and inflammation. A key class of lipid-derived signalling molecules involved in inflammation are the prostaglandins. ...
    • Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans 

      Whittle, Andrew J; Jiang, Meizi; Peirce, Vivian; Relat, Joana; Virtue, Samuel; Ebinuma, Hiroyuki; Fukamachi, Isamu et al. (Nature Publishing Group, 2015-11-20)
      Thermogenesis in brown adipose tissue (BAT) is an important component of energy expenditure in mammals. Recent studies have confirmed its presence and metabolic role in humans. Defining the physiological regulation of BAT ...
    • Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases 

      Rodriguez-Cuenca, Sergio; Pellegrinelli, Vanessa Florence; Campbell, M; Oresic, M; Vidal-Puig, Antonio (Elsevier, 2017-04-01)
      Sphingolipids in general and ceramides in particular, contribute to pathophysiological mechanisms by modifying signalling and metabolic pathways. Here, we present the available evidence for a bidirectional homeostatic ...