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    • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. 

      Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, Linsey et al. (2016-10-11)
      BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive ...