Now showing items 1-4 of 4

    • Human cytomegalovirus miR-UL112-1 promotes the down-regulation of viral immediate early gene expression during latency to prevent T cell recognition of latently infected cells 

      Lau, Betty; Poole, Emma; Van Damme, Ellen; Bunkens, Lieve; Sowash, Madeleine; King, Harry; Murphy, Eain et al. (Microbiology Society, 2016-07-13)
      Human cytomegalovirus (HCMV), a member of the herpesvirus family, can cause significant morbidity and mortality in immune compromised patients resulting from either primary lytic infection or reactivation from latency. ...
    • Immunosenescence and Cytomegalovirus: where do we stand after a decade? 

      Pawelec, Graham; Akbar, Arne; Beverley, Peter; Caruso, Calogero; Derhovanessian, Evelyna; Fulop, Tamas; Griffiths, Paul et al. (2010-09-07)
      AbstractSince Looney at al. published their seminal paper a decade ago it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated ...
    • Latency-Associated Viral Interleukin-10 (IL-10) Encoded by Human Cytomegalovirus Modulates Cellular IL-10 and CCL8 Secretion during Latent Infection through Changes in the Cellular MicroRNA hsa-miR-92a 

      Poole, Emma; Avdic, Selmir; Hodkinson, Jemima; Jackson, Sarah; Wills, Mark; Slobedman, Barry; Sinclair, John (American Society for Microbiology, 2014-09-24)
      The UL111A gene of human cytomegalovirus encodes a viral homologue of the cellular immunomodulatory cytokine interleukin 10 (cIL-10), which, due to alternative splicing, results in expression of two isoforms designated ...
    • Report from the Second Cytomegalovirus and Immunosenescence Workshop 

      Wills, Mark; Akbar, Arne; Beswick, Mark; Bosch, Jos A.; Caruso, Calogero; Colonna-Romano, Giuseppina; Dutta, Ambarish et al. (2011-10-28)
      Abstract The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory ...