Now showing items 1-3 of 3

    • Gene- or region-based association study via kernel principal component analysis 

      Gao, Qingsong; He, Yungang; Yuan, Zhongshang; Zhao, Jinghua; Zhang, Bingbing; Xue, Fuzhong (2011-08-26)
      Abstract Background In genetic association study, especially in GWAS, gene- or region-based methods have been more popular to detect the association between multiple SNPs and diseases (or traits). Kernel principal component ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, Tuomas O.; Carli, Jayne F. Martin; Skowronski, Alicja A.; Sun, Qi; Kriebel, Jennifer; Feitosa, Mary F.; Hedman, Åsa K. et al. (Nature Publishing Group, 2016-02-01)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs 

      Peng, Qianqian; Zhao, Jinghua; Xue, Fuzhong (2010-01-26)
      Abstract Background Genetic association study is currently the primary vehicle for identification and characterization of disease-predisposing variant(s) which usually involves multiple single-nucleotide polymorphisms ...