Now showing items 1-5 of 5

    • Integrating systems biology models and biomedical ontologies 

      Hoehndorf, Robert; Dumontier, Michel; Gennari, John H.; Wimalaratne, Sarala; de Bono, Bernard; Cook, Daniel L.; Gkoutos, Georgios V. (2011-08-11)
      Abstract Background Systems biology is an approach to biology that emphasizes the structure and dynamic behavior of biological systems and the interactions that occur within them. To succeed, systems biology crucially ...
    • TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils 

      Radjabova, Valeria; Mastroeni, Piero; Skjødt, Karsten; Zaccone, Paola; de Bono, Bernard; Goodall, Jane C.; Chilvers, Edwin R. et al. (American Association of Immunologists, 2015-08-26)
      We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell–interacting, activating receptor on myeloid cells-1 ...
    • TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils 

      Radjabova, Valeria; Mastroeni, Piero; Skjødt, Karsten; Zaccone, Paola; de Bono, Bernard; Goodall, Jane C.; Chilvers, Edwin R. et al. (American Association of Immunologists, 2015-08-26)
      We identified a novel, evolutionarily conserved receptor encoded within the human Leukocyte Receptor Complex (LRC) and syntenic region of mouse chromosome 7, named T cell interacting, activating receptor on myeloid cells-1 ...
    • The RICORDO approach to semantic interoperability for biomedical data and models: strategy, standards and solutions. 

      de Bono, Bernard; Hoehndorf, Robert; Wimalaratne, Sarala; Gkoutos, George; Grenon, Pierre (2011-08-30)
      Abstract Background The practice and research of medicine generates considerable quantities of data and model resources (DMRs). Although in principle biomedical resources are re-usable, in practice few can currently be ...
    • Transcriptional diversity during lineage commitment of human blood progenitors 

      Chen, Lu; Kostadima, Myrto; Martens, Joost H.A.; Canu, Giovanni; Garcia, Sara P.; Turro, Ernest; Downes, Kate et al. (AAAS, 2014-09-26)
      Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice we sequenced RNA from eight primary human hematopoietic progenitor populations ...