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    • Haploinsufficiency and the sex chromosomes from yeasts to humans 

      de Clare, Michaela; Pir, Pinar; Oliver, Stephen G (2011-02-28)
      Abstract Background Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness. Haploinsufficiency is increasingly implicated in human ...