Now showing items 1-2 of 2

    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis. 

      Harrison, Seamus C; Holmes, Michael V; Burgess, Stephen; Asselbergs, Folkert W; Jones, Gregory T; Baas, Annette F; van 't Hof, FN et al. (2018-01)
      Importance: Risk factors for abdominal aortic aneurysm (AAA) are largely unknown, which has hampered the development of nonsurgical treatments to alter the natural history of disease. Objective: To investigate the association ...