Now showing items 1-5 of 5

    • Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists 

      Silva, Ana-Luisa; Dawson, Sarah N.; Arends, Mark J.; Guttula, Kiran; Hall, Nigel; Cameron, Ewen A.; Huang, Tim H.-M. et al. (BioMed Central, 2014-11-29)
      Background: There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive ...
    • Intracellular shuttling of a Drosophila APC tumour suppressor homolog 

      Cliffe, Adam; Mieszczanek, Julius; Bienz, Mariann (2004-09-30)
      Abstract Background The Adenomatous polyposis coli (APC) tumour suppressor is found in multiple discrete subcellular locations, which may reflect sites of distinct functions. In Drosophila epithelial cells, the predominant ...
    • Pregnancy, Primary Aldosteronism and Somatic CTNNB1 Mutations in the Adrenal 

      Teo, Ada E. D.; Garg, Sumedha; Shaikh, Lalarukh Haris; Zhou, Junhua; Karet Frankl, Fiona E.; Gurnell, Mark; Happerfield, Lisa et al. (Massachusetts Medical Society, 2015-10-08)
      Recent discoveries of somatic mutations permit the recognition of sub-types of aldosterone-producing adenomas (APA) with different clinical presentations and pathology. Here we describe two women who presented in pregnancy, ...
    • Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations 

      Teo, Ada E. D.; Garg, Sumedha; Shaikh, Lalarukh Haris; Zhou, Junhua; Karet Frankl, Fiona E.; Gurnell, Mark; Happerfield, Lisa et al. (Massachusetts Medical Society, 2015-09-23)
      Recent discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas with distinct clinical presentations and pathological features. Here we describe three women with hyperaldosteronism, ...
    • The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells 

      de la Roche, Marc; Worm, Jesper; Bienz, Mariann (2008-07-15)
      Abstract Background Most cases of colorectal cancer are initiated by hyperactivation of the Wnt/β-catenin pathway due to mutations in the APC tumour suppressor, or in β-catenin itself. A recently discovered ...