Browsing by Author "Cutler, Antony J"
Now showing items 1-5 of 5
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Chromosome contacts in activated T cells identify autoimmune disease candidate genes
Burren, Oliver S; Rubio García, Arcadio; Javierre, Biola-Maria; Rainbow, Daniel B; Cairns, Jonathan; Cooper, Nicholas J; Lambourne, John JSchofield, EllenCastro Dopico, XaquinFerreira, Ricardo CCoulson, RichardBurden, FrancesRowlston, Sophia PDownes, KateWingett, Steven WFrontini, MattiaOuwehand, Willem HFraser, PeterSpivakov, MikhailTodd, John AWicker, Linda SCutler, Antony JWallace, Chris et al. (2017-09-04)Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory ... -
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Javierre, Biola M; Burren, Oliver S; Wilder, Steven P; Kreuzhuber, Roman; Hill, Steven M; Sewitz, Sven; Cairns, JonathanWingett, Steven WVárnai, CsillaThiecke, Michiel JBurden, FrancesFarrow, SamanthaCutler, Antony JRehnstrom, KarolaDownes, KateGrassi, LuigiKostadima, MyrtoFreire-Pritchett, PaulaWang, FanThe, BLUEPRINT ConsortiumStunnenberg, Hendrik GTodd, John AZerbino, Daniel RStegle, OliverOuwehand, Willem HendrikFrontini, MattiaWallace, ChrisSpivakov, MikhailFraser, Peter et al. (2016-11-17) -
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Javierre, Biola M; Burren, Oliver S; Wilder, Steven P; Kreuzhuber, Roman; Hill, Steven Mark; Sewitz, Sven; Cairns, JonathanWingett, Steven WVárnai, CsillaThiecke, Michiel JBurden, FrancesFarrow, SamanthaCutler, Antony JRehnstrom, KarolaDownes, KateGrassi, LuigiKostadima, MyrtoFreire-Pritchett, PaulaWang, FanThe, BLUEPRINT ConsortiumStunnenberg, Hendrik GTodd, John AZerbino, Daniel RStegle, OliverOuwehand, Willem HendrikFrontini, MattiaWallace, ChrisSpivakov, MikhailFraser, Peter et al. (Elsevier (Cell Press), 2016-11-17)Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome ... -
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, LinseySmyth, Deborah JRainbow, Daniel BFerreira, Ricardo CEsposito, LauraHunter, Kara MDLoudon, KevinIrons, KathrynYang, Jennie HBell, Charles JMSchuilenburg, HelenHeywood, JamesChallis, BenNeupane, SankalpaClarke, PamelaColeman, GillianDawson, SarahGoymer, DonnaAnselmiova, KaterinaKennet, JaneBrown, JudyCaddy, SarahLu, JiaGreatorex, JaneGoodfellow, Ian GordonWallace, ChrisTree, Tim IEvans, MarkMander, Adrian PaulBond, SimonWicker, Linda SWaldron-Lynch, Frank et al. (2016-10-11)BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive ... -
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial
Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, LinseySmyth, Deborah JRainbow, Daniel BFerreira, Ricardo CEsposito, LauraHunter, Kara MDLoudon, KevinIrons, KathrynYang, Jennie HBell, Charles JMSchuilenburg, HelenHeywood, JamesChallis, BenNeupane, SankalpaClarke, PamelaColeman, GillianDawson, SarahGoymer, DonnaAnselmiova, KaterinaKennet, JaneBrown, JudyCaddy, SarahLu, JiaGreatorex, JaneGoodfellow, Ian GordonWallace, ChrisTree, Tim IEvans, Mark LewisMander, Adrian PaulBond, SimonWicker, Linda SWaldron-Lynch, Frank et al. (Public Library of Science, 2016-10-11)$\textbf{Background}$ Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4$^+$ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and ...