Browsing by Author "Cutler, Antony J"

Now showing items 1-5 of 5

    • Chromosome contacts in activated T cells identify autoimmune disease candidate genes 

      Burren, Oliver S; Rubio García, Arcadio; Javierre, Biola-Maria; Rainbow, Daniel B; Cairns, Jonathan; Cooper, Nicholas J; Lambourne, John J et al. (2017-09-04)
      Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory ...

    • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters 

      Javierre, Biola M; Burren, Oliver S; Wilder, Steven P; Kreuzhuber, Roman; Hill, Steven M; Sewitz, Sven; Cairns, Jonathan et al. (2016-11-17)

    • Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters 

      Javierre, Biola M; Burren, Oliver S; Wilder, Steven P; Kreuzhuber, Roman; Hill, Steven Mark; Sewitz, Sven; Cairns, Jonathan et al. (Elsevier (Cell Press), 2016-11-17)
      Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome ...

    • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial 

      Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, Linsey et al. (2016-10-11)
      BACKGROUND: Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4+ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and regulate autoreactive ...

    • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial 

      Todd, John A; Evangelou, Marina; Cutler, Antony J; Pekalski, Marcin L; Walker, Neil M; Stevens, Helen E; Porter, Linsey et al. (Public Library of Science, 2016-10-11)
      $\textbf{Background}$ Interleukin-2 (IL-2) has an essential role in the expansion and function of CD4$^+$ regulatory T cells (Tregs). Tregs reduce tissue damage by limiting the immune response following infection and ...