Now showing items 1-10 of 10

    • Association analysis identifies 65 new breast cancer risk loci 

      Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; Kar, S; Lemaçon, A et al. (Nature Publishing Group, 2017-10-23)
      Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...
    • Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis 

      Lotta, Luca Andrea; Sharp, Stephen John; Burgess, Stephen; Perry, John Richard; Stewart, Isobel Dorothea; Willems, Sara Marie; Luan, Jian'an et al. (American Medical Association, 2016-10-04)
      IMPORTANCE: Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near $\textit{NPC1L1}$ or $\textit{HMGCR}$, encoding the respective molecular targets of ezetimibe and statins, have previously been used as ...
    • Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition 

      Caini, S; Masala, G; Saieva, C; Kvaskoff, M; Savoye, I; Sacerdote, C; Hemmingsson, O et al. (John Wiley & Sons Inc., 2017-02-20)
      In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma, however epidemiological evidence is limited to date. We examined the relationships ...
    • Common germline polymorphisms associated with breast cancer specific survival 

      Pirie, A; Guo, Qi; Kraft, P; Canisius, S; Eccles, DM; Rahman, N; Nevanlinna, H et al. (2015-04-22)
    • Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort. 

      Obón-Santacana, M; Lujan-Barroso, L; Freisling, H; Cadeau, C; Fagherazzi, G; Boutron-Ruault, M-C; Kaaks, R et al. (Springer, 2017-04)
      PURPOSE: Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, ...
    • Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium 

      Barrdahl, M; Rudolph, A; Hopper, JL; Southey, MC; Broeks, A; Fasching, PA; Beckmann, MW et al.
      Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions. We assessed the interplay between 70 single nucleotide polymorphisms identified ...
    • Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from EPIC-InterAct 

      Li, Xueyi; Imamura, F; Ye, Zheng; Schulze, MB; Zheng, J; Ardamaz, E; Arriola, L et al. (American Society for Clinical Nutrition, Inc., 2017-06-07)
      Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to ...
    • Measured adiposity in relation to head and neck cancer risk in the European Prospective Investigation into Cancer and Nutrition 

      Ward, HA; Wark, PA; Muller, DC; Steffen, A; Johansson, M; Norat, T; Gunter, MJ et al.
      BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to ...
    • Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. 

      InterAct, Consortium; Romaguera, D; Guevara, M; Norat, T; Langenberg, Claudia; Forouhi, Nita Gandhi; Sharp, S et al. (American Diabetes Association, 2011-09)
      OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort ...
    • Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition 

      Perez-Cornago, A; Appleby, PN; Tipper, S; Key, TJ; Allen, NE; Nieters, A; Vermeulen, R et al. (John Wiley & Sons Inc., 2017-01-18)
      Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. ...