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    • The RyR2-P2328S mutation downregulates Nav1.5 producing a ventricular arrhythmic substrate in murine ventricles. 

      Ning, Feifei; Luo, Ling; Ahmad, Shiraz; Valli, Haseeb; Jeevaratnam, Kamalan; Wang, Tingzhong; Guzadhur, Laila et al. (Springer, 2015-11-06)
      Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca2+ homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous ...