Now showing items 1-4 of 4

    • Astrocyte activation via Stat3 signalling determines the balance of oligodendrocyte versus Schwann cell remyelination 

      Castro, Glaucia Monteiro de; Deja, Natalia; Ma, Dan; Zhao, Chao; Franklin, Robin James (2015-07-17)
      Remyelination within the central nervous system (CNS) most often is the result of oligodendrocyte progenitor cells differentiating into myelin-forming oligodendrocytes. In some cases, however, Schwann cells, the peripheral ...
    • Efficient Remyelination Requires DNA Methylation 

      Moyon, Sarah; Ma, Dan; Huynh, Jimmy L; Coutts, David JC; Zhao, Chao; Casaccia, Patrizia; Franklin, Robin James (Society for Neuroscience, 2017)
      Oligodendrocyte progenitor cells (OPCs) are the principal source of new myelin in the central nervous system. A better understanding of how they mature into myelin-forming cells is of high relevance for remyelination. It ...
    • Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage 

      Moyon, S; Huynh, JL; Dutta, D; Zhang, F; Ma, Dan; Yoo, S; Lawrence, R et al. (Elsevier, 2016-04-26)
      Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and multiple transgenic lines, this study defines ...
    • Sox2 sustains recruitment of oligodendrocyte progenitor cells following CNS demyelination and primes them for differentiation during CNS remyelination 

      Zhao, Robin James; Ma, Dan; Zawadzka, Malgorzata; Fancy, Stephen PJ; Elis-Williams, Lowri; Bouvier, Guy; Stockley, John Henry et al. (2015-08-19)
      UNLABELLED: The Sox family of transcription factors have been widely studied in the context of oligodendrocyte development. However, comparatively little is known about the role of Sox2, especially during CNS remyelination. ...