Now showing items 1-5 of 5

    • Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform 

      Saar, Kadi Liis; Yates, Emma V; Müller, Thomas; Saunier, Séverine; Dobson, Christopher Martin; Knowles, Tuomas Pertti
      Increasingly prevalent neurodegenerative diseases are associated with the formation of nanoscale amyloid aggregates from normally soluble peptides and proteins. A widely used strategy for following the aggregation process ...
    • Enhancing power density of biophotovoltaics by decoupling storage and power delivery 

      Saar, Kadi Liis; Bombelli, P; Lea-Smith, DJ; Call, Toby; Aro, EM; Müller, T; Howe, Christopher Jonathan et al. (2018-01-01)
      Biophotovoltaic devices (BPVs), which use photosynthetic organisms as active materials to harvest light, have a range of attractive features relative to synthetic and non-biological photovoltaics, including their environmentally ...
    • Gradient-free determination of isoelectric points of proteins on chip 

      Łapińska, U; Saar, Kadi Liis; Yates, EV; Herling, Therese Windelborg; Müller, T; Challa, Pavan Kumar; Dobson, Christopher Martin et al. (Royal Society of Chemistry, 2017-09-14)
      The isoelectric point (pI) of a protein is a key characteristic that influences its overall electrostatic behaviour. The majority of conventional methods for the determination of the isoelectric point of a molecule rely ...
    • Microfluidic approaches for probing amyloid assembly and behaviour. 

      Herling, Therese Windelborg; Levin, Aviad; Saar, Kadi Liis; Dobson, Christopher Martin; Knowles, Tuomas Pertti (RSC, 2018-03)
      The self-assembly of proteins into supra-molecular structures and machinery underpins biologi- cal activity in living systems. Misassembled, misfolded and aggregated protein structures can, by contrast, have deleterious ...
    • On-chip measurements of protein unfolding from direct observations of micron-scale diffusion. 

      Zhang, Yuewen; Yates, Emma V; Hong, Liu; Saar, Kadi Liis; Meisl, Georg; Dobson, Christopher Martin; Knowles, Tuomas Pertti (Chemical Science, 2018-04)
      Investigations of protein folding, unfolding and stability are critical for the understanding of the molecular basis of biological structure and function. We describe here a microfluidic approach to probe the unfolding of ...