Now showing items 1-12 of 12

    • Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. 

      Spector, Tim D; Calomme, Mario R; Anderson, Simon H; Clement, Gail; Bevan, Liisa; Demeester, Nathalie; Swaminathan, Rami et al. (2008-06-11)
      Abstract Background Mounting evidence supports a physiological role for silicon (Si) as orthosilicic acid (OSA, Si(OH)4) in bone formation. The effect of oral choline-stabilized orthosilicic acid (ch-OSA) on markers of ...
    • Circulating Proteomic Signatures of Chronological Age. 

      Menni, Cristina; Kiddle, Steven John; Mangino, Massimo; Viñuela, Ana; Psatha, Maria; Steves, Claire; Sattlecker, Martina et al. (2015-07)
      To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent ...
    • Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek et al. (2016-06-29)
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 

      International Consortium for Blood Pressure Genome-Wide Association Studies,; Ehret, Georg B; Munroe, Patricia B; Rice, Kenneth M; Bochud, Murielle; Johnson, Andrew D; Chasman, Daniel I et al. (2011-09-11)
    • Genetic variation at 16q24.2 is associated with small vessel stroke. 

      Traylor, Matthew Stephen; Malik, Rainer; Nalls, Mike A; Cotlarciuc, Ioana; Radmanesh, Farid; Thorleifsson, Gudmar; Hanscombe, Ken B et al. (Wiley, 2017-03)
      OBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. 

      Wain, Louise V; Verwoert, Germaine C; O'Reilly, Paul F; Shi, Gang; Johnson, Toby; Johnson, Andrew D; Bochud, Murielle et al. (2011-09-11)
    • Genome-wide association study with 1000 genomes imputation identifies signals for nine sex-hormone-related phenotypes 

      Ruth, Katherine S; Campbell, Purdey J; Chew, Shelby; Lim, Ee Mun; Hadlow, Narelle; Stuckey, Bronwyn GA; Brown, Suzanne J et al. (Nature Publishing Group, 2015-05-20)
      Genetic factors contribute strongly to sex-hormone levels, yet knowledge of the regulatory mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified only a small number of loci associated with ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, Tuomas O; Carli, Jayne F Martin; Skowronski, Alicja A; Sun, Qi; Kriebel, Jennifer; Feitosa, Mary F; Hedman, Åsa K et al. (Nature Publishing Group, 2016-02-01)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility 

      Mbarek, Hamdi; Steinberg, Stacy; Nyholt, Dale R; Gordon, Scott D; Miller, Michael B; McRae, Allan F; Hottenga, Jouke Jan et al. (Elsevier, 2016-04-28)
      Spontaneous dizygotic (DZ) twinning occurs in 1%–4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications ...
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John Richard; Yuan, Xin; Scott, Robert; Henneman, Peter et al. (2012-01)
    • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. 

      Perry, John Richard; Day, Felix Ranulf; Elks, Cathy; Sulem, Patrick; Thompson, Deborah Jane; Ferreira, Teresa; He, Chunyan et al. (2014-10)