Now showing items 1-3 of 3

    • Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. 

      Warren, HR; Evangelou, E; Cabrera, CP; Gao, H; Ren, M; Mifsud, B; Ntalla, I et al. (Nature Publishing Group, 2017-03-01)
      Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of ...
    • Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

      Zhao, W; Rasheed, A; Tikkanen, E; Lee, J-J; Butterworth, Adam Stuart; Howson, Joanna McCammond; Assimes, TL et al.
      To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D ...
    • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

      Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N et al. (American Diabetes Association, 2017-03-23)
      To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...