Now showing items 1-5 of 5

    • Association analysis identifies 65 new breast cancer risk loci 

      Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; Kar, S; Lemaçon, A et al. (Nature Publishing Group, 2017-10-23)
      Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...
    • Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21 

      Hamdi, Y; Soucy, P; Adoue, V; Michailidou, Kyriaki; Canisius, S; Lemaçon, A; Droit, A et al. (Impact Journals, 2016-10-21)
      There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, $\textit{cis}$-acting variants represent an important source of phenotypic variation. Consequently, ...
    • Common germline polymorphisms associated with breast cancer specific survival 

      Pirie, A; Guo, Qi; Kraft, P; Canisius, S; Eccles, DM; Rahman, N; Nevanlinna, H et al. (BioMed Central, 2015-04-22)
      Introduction Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was ...
    • A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density 

      Rudolph, A; Fasching, PA; Behrens, S; Eilber, U; Bolla, Manjeet Kaur; Wang, Qin; Thompson, Deborah Jane et al. (BioMed Central, 2015-08-16)
      Introduction: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants ...
    • rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk 

      Liu, J; Lončar, I; Collée, JM; Bolla, MK; Dennis, J; Michailidou, K; Wang, Qin et al. (Nature Publishing Group, 2016-12)
      NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated ...