Now showing items 1-2 of 2

    • Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes 

      Temprano, Ana; Sembongi, Hiroshi; Han, Gil-Soo; Sebastián, David; Capellades, Jordi; Moreno, Cristóbal; Guardiola, Juan et al. (Springer, 2016)
      Aims/hypothesis In mammals, the evolutionary conserved family of Mg$^{2+}$-dependent phosphatidate phosphatases (PAP1), involved in phospholipid and triacylglycerol synthesis, consists of lipin-1, lipin-2 and lipin-3. ...
    • Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene 

      Wabitsch, Martin; Funcke, Jan-Bernd; Schnurbein, Julia von; Denzer, Friederike; Lahr, Georgia; Mazen, Inas; El-Gammal, Mona et al. (Endocrine Society, 2015-07-17)
      Context: Congenital leptin deficiency is a very rare cause of severe early-onset obesity. We recently characterized a mutation in the leptin gene (p.D100Y), which was associated with detectable leptin levels and bioinactivity ...