Now showing items 1-4 of 4

    • Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis 

      Carr, Edward Joseph; Niederer, Heather A; Williams, Julie; Harper, Lorraine; Watts, Richard A; Lyons, Paul Anthony; Smith, Kenneth George (2009-12-01)
      Abstract Background The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not well defined. Across different autoimmune diseases some genes with immunomodulatory ...
    • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 

      Sims, Rebecca; van der Lee, Sven J; Naj, Adam C; Bellenguez, Céline; Badarinarayan, Nandini; Jakobsdottir, Johanna; Kunkle, Brian W et al. (2017-09)
      We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested ...
    • Shared genetic contribution to Ischaemic Stroke and Alzheimer’s Disease 

      Traylor, Matthew Stephen; Adib-Samii, Poneh; Harold, Denise; Dichgans, Martin; Williams, Julie; Lewis, Cathryn M; Markus, Hugh Stephen (Wiley, 2016-03-30)
      Objective Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two ...
    • The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans. 

      Khabirova, Eleonora; Moloney, Aileen; Marciniak, Stefan John; Williams, Julie; Lomas, David A; Oliver, Stephen George; Favrin, Giorgio et al. (2014-01)