Now showing items 1-9 of 9

    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Exome-wide association study of plasma lipids in >300,000 individuals. 

      Liu, Dajiang J; Peloso, Gina M; Yu, Haojie; Butterworth, Adam Stuart; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish et al. (Springer Nature, 2017-12)
      We report four novel loci associated with blood pressure regulation, and one independent variant at an established blood pressure locus. This analysis highlights several candidate genes with variation that alters protein ...
    • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

      Yaghootkar, Hanieh; Lotta, Luca Andrea; Tyrrell, Jessica; Smit, Roelof AJ; Jones, Sam E; Donnelly, Louise; Beaumont, Robin et al. (American Diabetes Association, 2016-04-26)
      Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These “favorable adiposity” alleles are collectively associated with lower ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. 

      Lotta, Luca Andrea; Gulati, Pawan; Day, Felix Ranulf; Payne, Felicity; Ongen, Halit; van, de Bunt Martijn; Gaulton, Kyle J et al. (Nature Publishing Group, 2017-01)
      Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

      Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P et al. (Springer Nature, 2018-01)
      Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which ...
    • Testing the Role of Predicted Gene Knockouts in Human Anthropometric Trait Variation 

      Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia et al. (Oxford University Press, 2016-02-21)
      Although the role of complete gene inactivation by two loss-of-function mutations inherited in trans is well-established in recessive Mendelian diseases, we have not yet explored how such gene knockouts (KOs) could influence ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels et al. (Nature Publishing Group, 2016-09-12)
      High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we ...