Now showing items 1014-1033 of 219035

• #### A simple Bayesian estimate of direct RNAi gene regulation events from differential gene expression profiles ﻿

(2011-05-20)
Abstract Background Microarrays are commonly used to investigate both the therapeutic potential and functional effects of RNA interfering (RNAi) oligonucleotides such as microRNA (miRNA) and small interfering RNA (siRNA). ...
• #### A simple introduction to the economics of storage: shifting demand and supply over time and space ﻿

(Faculty of Economics, 2016-12-01)
The literature on electrical energy storage (EES) is technical and complex which this paper aims to simplify. It quantifies the current scale, costs and value of different types of EES and compares them to peaking generators ...
• #### A Simulation Approach to the Study of Bacterial Secretion Proteins ﻿

(2017-07-22)
Knowledge of the structure and dynamics of cellular protein complexes is essential for understanding their functionally relevant interactions. In Gram-negative bacteria, the complex machinery associated with the type II ...
• #### A Social Cost Benefit Analysis of Grid-Scale Electrical Energy Storage Projects: Evaluating the Smarter Network Storage Project ﻿

(Faculty of Economics, 2017-05-23)
This study explores and quantifies the social costs and benefits of grid-scale electrical energy storage (EES) projects in Great Britain. The case study for this report is the Smarter Network Storage project, a 6 MW/10MWh ...
• #### A socio-cultural study exploring Greek and English 11-year-old children's responses to wordless picturebooks ﻿

(2017-10-06)
This thesis investigates how Greek and English 11-year-old students respond to wordless picturebooks. Through the identification of themes in their responses, the study explores the children's engagement while interpreting ...
• #### A straightforward method to compute average stochastic oscillations from data samples ﻿

(2015-10-19)
Abstract Background Many biological systems exhibit sustained stochastic oscillations in their steady state. Assessing these oscillations is usually a challenging task due to ...
• #### A structural role for the PHP domain in E. coli DNA polymerase III ﻿

(2013-05-14)
Abstract Background In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains ...
• #### A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1 ﻿

(2010-07-14)
Abstract Synaptic transmission and long-term potentiation (LTP) in the CA1 region of hippocampal slices have been studied during ageing of a double transgenic mouse strain relevant to early-onset familial Alzheimer's disease ...
• #### A system operator's utility function for the frequency response market ﻿

(Faculty of Economics, 2017-07-10)
How can the electricity system operator determine the optimal quantity and quality of electricity ancillary services (such as frequency response) to procure in a market increasingly characterized by intermittent renewable ...
• #### A Systems Perspective on Standardisation in Technological Innovation: A Conceptual Framework and a Process Model Supporting Strategic Policy Foresight ﻿

(2017-01-30)
This thesis addresses conceptual and practical challenges in anticipating potential standardisation needs and developing relevant strategies throughout various stages of technological innovation. With increasing awareness ...
• #### A Toolbox for Predicting G-Quadruplex Formation and Stability ﻿

(2010-6-8)
G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding. Many of these structures are highly thermally stable, especially in the presence ...
• #### A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study ﻿

(2011-01-28)
Abstract Background A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus ...
• #### A VCG Auction for Electricity Storage ﻿

(Faculty of Economics, 2016-04-25)
Energy storage seems set to play a key role in managing and balancing the future electricity system. Storage can act as a generator and as a load, providing both energy and ancillary services such as fast frequency response ...
• #### A whole genome screen for HIV restriction factors ﻿

(2011-11-14)
Abstract Background Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immunodeficiency virus (HIV) human restriction factors, APOBEC3 (apolipoprotein-B-mRNA-editi ...
• #### A world allergy organization international survey on diagnostic procedures and therapies in drug allergy/hypersensitivity ﻿

(2011-12-15)
Abstract Objective To study the diagnostic and treatment modalities used in drug allergy/hypersensitivity among members of the World Allergy Organization (WAO). Methods A questionnaire comprising 39 questions was circulated ...
• #### An a$_{0}$ resonance in strongly coupled πη, K$\bar K$ scattering from lattice QCD ﻿

(2016-05-11)
• #### A.I.P.R Bulletin ﻿

(Australian Intitute of Psychic Research, 1985-01)
Near death experiences detailed in the A.I.P.R Bulletin includes an article by John Wren-Lewis.
• #### A.W.N. Pugin's English residential architecture in its context ﻿

(2004-04-27)
This Dissertation investigates all of A.W.N. Pugin’s known English residential architecture for the first time, placing it in the context of the domestic and institutional architecture of comparable small buildings, ...
• #### A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction ﻿

Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer’s disease in an initial ...
• #### The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. ﻿

(Rockefeller University Press, 2007-01-08)
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to ...