Now showing items 11853-11872 of 218233

    • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis 

      Lotta, Luca Andrea; Scott, Robert; Sharp, Stephen John; Burgess, Stephen; Luan, Jian'an; Tillin, T; Schmidt, AF et al. (PLoS, 2016-11-29)
      $\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
    • Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry 

      Cetica, Valentina; Sieni, Elena; Pende, Daniela; Danesino, Cesare; Fusco, Carmen de; Locatelli, Franco; Micalizzi, Concetta et al. (2015-09-02)
    • The Genetic Prehistory of the New World Arctic 

      Raghavan, Maanasa; DeGiorgio, Michael; Albrechtsen, Anders; Moltke, Ida; Skoglund, Pontus; Korneliussen, Thorfinn S; Grønnow, Bjarne et al. (2014-08-29)
    • Genetic Progression of Barrett's Oesophagus to Oesophageal Adenocarcinoma 

      Gregson, Eleanor M; Bornschein, Jan; Fitzgerald, Rebecca Clare (Nature Publishing Group, 2016)
      Barrett’s Oesophagus (BE) is the premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Diagnostically, p53 immunohistochemistry remains the only biomarker recommended clinically to aid ...
    • Genetic regulation of puberty timing in humans 

      Day, Felix Ranulf; Perry, John Richard; Ong, Ken (2015-05-07)
    • Genetic risk score Mendelian randomization shows obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer 

      Painter, Jodie N; O’Mara, Tracy A; Marquart, Louise; Webb, Penelope M; for, the AOCS Group; Attia, John; Medland, Sarah E et al. (2016-08-22)
    • A genetic screen identifies a critical role for the WDR81-WDR91 complex in the trafficking and degradation of tetherin 

      Rapiteanu, Radu; Davis, Luther J; Williamson, James Colin; Timms, Richard Thomas; Luzio, John Paul; Lehner, Paul Joseph (2016-04-29)
      Tetherin (BST2/CD317) is a viral restriction factor that anchors enveloped viruses to host cells and limits viral spread. The HIV-1 Vpu accessory protein counteracts tetherin by decreasing its cell surface expression and ...
    • Genetic sex determination of mice by simplex PCR 

      Tunster, Simon J (2017-10-17)
      Abstract Background Investigating fetal development in mice necessitates the determination of fetal sex. However, whilst the sex of adult and juvenile mice can be readily ...
    • A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population 

      Marzec, Jacek; Mao, Xueying; Li, Meiling; Wang, Meilin; Feng, Ninghan; Gou, Xin; Wang, Guomin et al. (2016-02-08)
    • Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome 

      Di, Napoli Agnese; Warrier, Varun; Baron-Cohen, Simon; Chakrabarti, Bhismadev (2015-02-27)
    • Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. 

      Wright, Daniel; Day, Felix Ranulf; Kerrison, Nicola D; Zink, Florian; Cardona, Alexia; Sulem, Patrick; Thompson, Deborah Jane et al. (Nature Publishing Group, 2017-05)
      The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...
    • Genetic variation and gastric cancer risk: a field synopsis and meta-analysis 

      Mocellin, Simone; Verdi, Daunia; Pooley, Karen Anne; Nitti, Donato (2015-03-02)
    • Genetic variation at 16q24.2 is associated with small vessel stroke. 

      Traylor, Matthew; Malik, Rainer; Nalls, Mike A; Cotlarciuc, Ioana; Radmanesh, Farid; Thorleifsson, Gudmar; Hanscombe, Ken B et al. (Wiley, 2017-03)
      OBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS ...
    • Genetic variation in FOXO3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis 

      Viatte, Sebastien; Lee, James Christopher; Fu, Bo; Espéli, Marion; Lunt, Mark; De, Wolf Jack NE; Wheeler, Lily et al. (2016-05-23)
    • Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies 

      Kelemen, Linda E; Couch, Fergus J; Ahmed, Shahana; Dunning, Alison Margaret; Pharoah, Paul David; Easton, Douglas Frederick; Fredericksen, Zachary S et al. (2008-11-26)
    • Genetic variation in the IFITM locus and its phenotypic consequences 

      Diaz Soria, Carmen Lidia (2017-10-01)
      In the past few years, interferon-induced transmembrane (IFITM) proteins have been identified as important antiviral factors. The current understanding of IFITMs suggests that they localise within distinct cellular ...
    • Genetic variation in the immunosuppression pathway genes and breast cancer: a pooled analysis of 42,510 cases and 40,577 controls from the Breast 

      Lei, Jieping; Rudolph, Anja; Moysich, Kirsten B; Behrens, Sabine; Goode, Ellen L; Bolla, Manjeet K; Dennis, Joe et al. (2015-11-30)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (2015-04-23)
    • Genetically diagnosed Birt–Hogg–Dubé syndrome and familial cerebral cavernous malformations in the same individual: a case report 

      Whitworth, James; Stausbøl-Grøn, Brian; Skytte, Anne-Bine (Springer, 2016-10-08)
      When faced with an unusual clinical feature in a patient with a Mendelian disorder, the clinician may entertain the possibilities of either the feature representing a novel manifestation of that disorder or the co-existence ...
    • Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration 

      Driskell, Iwona; Oeztuerk-Winder, Feride; Humphreys, Peter David; Frye, Michaela (2014-12-02)
      Adult mammalian epidermis contains multiple stem cell populations in which quiescent and more proliferative stem and progenitor populations co-exist. However, the precise interrelation of these populations in homeostasis ...