Now showing items 1956-1975 of 12439

    • Composition, development and function of uterine innate lymphoid cells 

      Doisne, Jean-Marc; Balmas, Elisa; Boulenouar, Selma; Gaynor, Louise M.; Kieckbusch, Jens; Gardner, Lucy; Hawkes, Delia A. et al. (American Association of Immunologists, 2015-09-14)
      Innate lymphoid cells (ILC), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells (uNK) in placentation and fetal growth, other uterine ILCs (uILCs) are ...
    • Compositional inhomogeneities as a source of indirect combustion noise 

      Magri, Luca; O’Brien, Jeff; Ihme, Matthias (Cambridge University Press, 2016-06-23)
      The generation of indirect combustion noise by compositional inhomogeneities is examined theoretically. For this, the compact-nozzle theory of Marble & Candel (J. Sound Vib., vol. 55 (2), 1977, pp. 225–243) is extended to ...
    • Comprehension of Globalization and Contemporary Fine Arts in China 

      Li, Yanli; Ren, Shizhong (Association of Cambridge Studies, 2007)
    • Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity 

      Nelson, AW; Groen, AJ; Miller, JL; Warren, AY; Holmes, KA; Tarulli, GA; Tilley, WD et al. (Elsevier BV, 2017-01-15)
      Estrogen Receptor-β (ERβ) has been implicated in many cancers. In prostate and breast cancer its function is controversial, but genetic studies implicate a role in cancer progression. Much of the confusion around ERβ stems ...
    • A comprehensive assessment of somatic mutation detection in cancer using whole genome sequencing 

      Alioto, Tyler S.; Buchhalter, Ivo; Derdak, Sophia; Hutter, Barbara; Eldridge, Matthew D.; Hovig, Eivind; Heisler, Lawrence E. et al. (Nature Publishing Group, 2015)
      As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from two different ...
    • A Comprehensive Case Study of Macrosegregation in a Steel Ingot 

      Pickering, Ed J.; Chesman, Connor; Al-Bermani, Sinan; Holland, Melanie; Davies, Peter; Talamantes-Silva, Jesus (Springer, 2015-06-09)
      A case study is presented that examines the macrosegregation and grain structure present in a 12-tonne steel ingot, which was cast for experimental purposes. Details of the casting procedure were well documented and the ...
    • A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density 

      Rudolph, A.; Fasching, P. A.; Behrens, S.; Eilber, U.; Bolla, M. K.; Wang, Q.; Thompson, D. et al. (BioMed Central, 2015-08-16)
      Introduction: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants ...
    • A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV) 

      Shaikh, SS; Chen, YC; Halsall, SA; Nahorski, MS; Omoto, K; Young, GT; Phelan, A et al. (John Wiley & Sons Inc., 2017-01-01)
      Hereditary sensory and autonomic neuropathy type IV (HSAN IV) is an autosomal recessive disorder characterized by a complete lack of pain perception and anhidrosis. Here, we studied a cohort of seven patients with HSAN IV ...
    • Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer 

      O'Mara, Tracy A.; Glubb, Dylan M.; Painter, Jodie N.; Cheng, Timothy; Dennis, Joe; Australian National Endometrial Cancer Study Group (ANECS); Attia, John et al. (Society for Endocrinology, 2015-08-30)
      Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. The physiological function of estrogen is primarily mediated by estrogen ...
    • A comprehensive high-throughput sequencing test for the diagnosis of inherited bleeding, thrombotic and platelet disorders 

      Simeoni, Ilenia; Stephens, Jonathan C.; Hu, Fengyuan; Deevi, Sri V. V.; Megy, Karyn; Bariana, Tadbir K.; Lentaigne, Claire et al. (American Society of Hematology, 2016-04-15)
      Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for ...
    • Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH) 

      Chaudhuri, Roy R.; Allen, Andrew G.; Owen, Paul J.; Shalom, Gil; Stone, Karl; Harrison, Marcus; Burgis, Timothy A. et al. (2009-07-01)
      Abstract Background In recent years there has been an increasing problem with Staphylococcus aureus strains that are resistant to treatment with existing antibiotics. An important starting point for the development of new ...
    • A comprehensive meta-analysis of common genetic variants in Autism Spectrum Conditions 

      Warrier, Varun; Chee, Vivienne; Smith, Paula; Chakrabarti, Bhismadev; Baron-Cohen, Simon (2015-08-20)
      Background: Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by difficulties in social interaction and communication alongside repetitive and stereotyped behaviours. ASC are ...
    • Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells 

      Santos, David P.; Kiskinis, Evangelos; Eggan, Kevin; Merkle, Florian T. (Wiley, 2016-08-17)
      Application of the CRISPR/Cas9 system to edit the genomes of human pluripotent stem cells (hPSCs) has the potential to revolutionize hPSC-based disease modeling, drug screening, and transplantation therapy. Here, we aim ...
    • Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease 

      Carss, KJ; Arno, G; Erwood, M; Stephens, J; Sanchis-Juan, A; Hull, S; Megy, K et al. (Elsevier (Cell Press), 2017-01-05)
      Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who ...
    • Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ 

      Nicholas, A. K.; Serra, E. G.; Cangul, H.; Alyaarubi, S.; Ullah, I.; Schoenmakers, E.; Deeb, A. et al. (Endocrine Society, 2016-08-15)
      Context: Lower thyroid-stimulating hormone (TSH) screening cut-offs have doubled the ascertainment of congenital hypothyroidism (CH), particularly cases with a eutopically-located gland-in-situ (GIS). Although mutations ...
    • A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task? 

      Szucs, Zoltan; Davidson, Dochka; Wong, Han Hsi; Horan, Gail; Bearcroft, Philip W. P.; Grant, Ian; Grimer, Robert et al. (Hindawi Publishing Corporation, 2016-06-02)
      Background. National guidelines prompted the implementation of a designated two-week wait referral pathway to facilitate the early diagnosis of sarcomas, to improve treatment outcomes. Methods. Patients referred to the ...
    • Comprehensive Study of the CuF2 Conversion Reaction Mechanism in a Lithium Ion Battery 

      Hua, Xiao; Robert, Rosa; Du, Lin-Shu; Wiaderek, Kamila M.; Leskes, Michal; Chapman, Karena W.; Chupas, Peter J. et al. (American Chemical Society, 2014-06-11)
      Conversion materials for lithium ion batteries have recently attracted considerable attention due to their exceptional specific capacities. Some metal fluorides, such as CuF2, are promising candidates for cathode materials ...
    • Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. 

      Bickerton, George R.; Higueruelo, Alicia P.; Blundell, Tom L. (2011-07-29)
      Abstract Background Structural studies are increasingly providing huge amounts of information on multi-protein assemblies. Although a complete understanding of cellular processes will be dependent on an explicit characterization ...
    • Compressed Sensing Electron Tomography of Needle-Shaped Biological Specimens - Potential for Improved Reconstruction Fidelity with Reduced Dose 

      Saghi, Zineb; Divitini, Giorgio; Winter, Benjamin; Leary, Rowan; Spiecker, Erdmann; Ducati, Caterina; Midgley, Paul A. (Elsevier, 2015-10-30)
      Electron tomography is an invaluable method for 3D cellular imaging. The technique is, however, limited by the specimen geometry, with a loss of resolution due to a restricted tilt range, an increase in specimen thickness ...
    • Compressing Sets and Multisets of Sequences 

      Steinruecken, Christian (IEEE, 2015-02-12)
      This paper describes lossless compression algorithms for multisets of sequences, taking advantage of the multiset’s unordered structure. Multisets are a generalization of sets, where members are allowed to occur multiple ...