Now showing items 1996-2015 of 10374

    • CVD-Enabled Graphene Manufacture and Technology 

      Hofmann, Stephan; Braeuninger-Weimer, Philipp; Weatherup, Robert S. (ACS, 2015-06-26)
      [Image - see article] Integrated manufacturing is arguably the most challenging task in the development of technology based on graphene and other 2D materials, particularly with regard to the industrial demand for ...
    • CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study 

      Castellucci, Lea; Jamieson, Sarra E.; Miller, E. Nancy; Menezes, Eliane; Oliveira, Joyce; Magalhaes, Andrea; Guimaraes, Luiz Henrique et al. (2010-01-20)
      Abstract Background L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression ...
    • Cyanobacteria and eukaryotic algae use different chemical variants of vitamin B12 

      Helliwell, Katherine Emma; Lawrence, Andrew David; Holzer, Andre; Kudahl, Ulrich Johan; Sasso, Severin; Kräutler, Bernhard; Scanlan, David John et al. (Elsevier (Cell Press), 2016-03-31)
      Eukaryotic microalgae and prokaryotic cyanobacteria are the major components of the phytoplankton. Determining factors that govern growth of these primary producers, and how they interact, is therefore essential to ...
    • Cycling Li-O2 Batteries via LiOH Formation and Decomposition 

      Liu, Tao; Leskes, Michal; Yu, Wanjing; Moore, Amy J.; Zhou, Lina; Bayley, Paul M.; Kim, Gunwoo et al. (AAAS, 2015-10-30)
      The rechargeable aprotic Li-air (O₂) battery is a promising potential technology for next generation energy storage, but its practical realization still faces many challenges. In contrast to the standard Li-O₂ cells, which ...
    • Cycling provision separated from motor traffic: a systematic review exploring whether stated preferences vary by gender and age 

      Aldred, Rachel; Elliott, Bridget; Woodcock, James; Goodman, Anna (Taylor & Francis, 2016-07-14)
      In this paper we represent a systematic review of stated preference studies examining the extent to which cycle infrastructure preferences vary by gender and by age. A search of online, English-language academic and policy ...
    • Cyclopropanation using flow-generated diazo compounds 

      Roda, Nuria M.; Tran, Duc N.; Battilocchio, Claudio; Labes, Ricardo; Ingham, Richard J.; Hawkins, Joel M.; Ley, Steven V. (RSC, 2015-01-17)
      We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of ...
    • Cyfieithu iaith y caethweision yn Uncle Tom’s Cabin a darluniadau o siaradwyr ail iaith mewn llenyddiaeth Gymraeg 

      Willis, David (University of Wales Press, 2016)
      Uncle Tom’s Cabin, Harriett Beecher Stowe’s influential anti-slavery novel, appeared in eight different Welsh-language versions (translations, abridgements and adaptations) between 1852 and 1854. This paper looks at the ...
    • CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer. 

      Thompson, Deborah J.; O’Mara, Tracy A.; Glubb, Dylan M.; Painter, Jodie N.; Cheng, Timothy; Folkerd, Elizabeth; Doody, Deborah et al. (Bioscientifica, 2015-11-16)
      Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol concentrations. We analysed 2,937 SNPs in 6,608 endometrial cancer cases and 37,925 controls and report the ...
    • CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen 

      Abraham, Jean E.; Maranian, Mel J.; Driver, Kristy E.; Platte, Radka; Kalmyrzaev, Bolot; Baynes, Caroline; Luccarini, Craig et al. (2010-08-23)
      Abstract Introduction Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 ...
    • Cystic Fibrosis Foundation and European Cystic Fibrosis Society Consensus Recommendations for the Management of Nontuberculous Mycobacteria in Individuals with Cystic Fibrosis. 

      Floto, R. Andres; Olivier, Kenneth N.; Saiman, Lisa; Daley, Charles L.; Herrmann, Jean-Louis; Nick, Jerry A.; Noone, Peadar G. et al. (BMJ, 2015)
      Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). ...
    • Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiers 

      Tyzack, Jonathan D.; Mussa, Hamse Y.; Williamson, Mark J.; Kirchmair, Johannes; Glen, Robert C. (Chemistry Central, 2014-05-27)
      Background: The prediction of sites and products of metabolism in xenobiotic compounds is key to the development of new chemical entities, where screening potential metabolites for toxicity or unwanted side-effects is of ...
    • Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program 

      Park, Hyun Jung; Li, Juan; Hannah, Rebecca; Biddie, Simon; Leal-Cervantes, Ana I.; Kirschner, Kristina; Santa Cruz, David Flores et al. (Wiley, 2015-12-23)
      Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in ...
    • Cytokinin and auxin display distinct but interconnected distribution and signaling profiles to stimulate cambial activity 

      Immanen, Juha; Nieminen, Kaisa; Smolander, Olli-Pekka; Kojima, Mikiko; Serra, Juan Alonso; Koskinen, Patrik; Zhang, Jing et al. (Elsevier (Cell Press), 2016-07-14)
      Despite the crucial roles of phytohormones in plant development, comparison of the exact distribution profiles of different hormones within plant meristems has thus far remained scarce. Vascular cambium, a wide lateral ...
    • Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development 

      Lin, Andrew C; Tan, Chin Lik; Lin, Chien-Ling; Strochlic, Laure; Huang, Yi-Shuian; Richter, Joel D; Holt, Christine E (2009-03-02)
      Abstract Background Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for ...
    • Cytosolic PrP Can Participate in Prion-Mediated Toxicity 

      Thackray, Alana; Zhang, Chang; Arndt, Tina; Bujdoso, Raymond (American Society for Microbiology, 2014-05-07)
      Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants ...
    • C₄ photosynthesis in the rice paddy: insights from the noxious weed Echinochloa glabrescens 

      Covshoff, Sarah; Hughes, Thomas E.; Smith-Unna, Richard; Kelly, Steven; Szecowka, Marek; Bailey, Karen J.; Sage, Tammy L. et al. (American Society of Plant Biologists, 2015-11-02)
      The C₄ pathway is a highly complex trait that increases photosynthetic efficiency in over sixty plant lineages. Although the majority of C₄ plants occupy disturbed, arid and nutrient-poor habitats, some grow in high-nutrient, ...
    • D-modules on rigid analytic spaces I 

      Ardakov, Konstantin; Wadsley, Simon (De Gruyter, 2016)
      We introduce a sheaf of infinite order differential operators D on smooth rigid analytic spaces that is a rigid analytic quantisation of the cotangent bundle. We show that the sections of this sheaf over sufficiently small ...
    • DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-β Signaling and Suppresses Aldosterone Secretion. 

      Zhou, Junhua; Shaikh, Lalarukh Haris; Neogi, Sudeshna G.; McFarlane, Ian; Zhao, Wanfeng; Figg, Nichola; Brighton, Cheryl A. et al. (American Heart Association, 2015-03-16)
      Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (ZG)–like aldosterone-producing adenomas. We have therefore sought signature ZG genes, which may provide insight into the ...
    • Damage in biocomposites: Stiffness evolution of aligned plant fibre composites during monotonic and cyclic fatigue loading 

      Shah, Darshil U. (Elsevier, 2016)
      The non-linear stress-strain behaviour of plant fibre composites is well-known in the scientific community. Yet, the important consequences of this, in terms of the evolution of stiffness as a function of applied strain ...