Now showing items 2102-2121 of 19753

    • Carbon pools recover more quickly than plant biodiversity in tropical secondary forests. 

      Martin, Philip Anthony; Martin, Philip A; Newton, Adrian C; Bullock, James M (2013-12)
    • The carbon price: a toothless tool for material efficiency? 

      Skelton, Alexandra Clara; Allwood, Julian Mark (Royal Society Publishing, 2017-06-13)
      This article explores whether a carbon price will effectively encourage the more efficient use of greenhouse gas intensive materials such as steel. The article identifies a range of distortions that arise when some of the ...
    • Carbon residence time dominates uncertainty in terrestrial vegetation responses to future climate and atmospheric CO2 

      Friend, Andrew David; Lucht, Wolfgang; Rademacher, Tim T; Keribin, Rozenn; Betts, Richard; Patricia, Cadule; Ciais, Philippe et al. (PNAS, 2014-03-04)
      Future climate change and increasing atmospheric CO2 are expected to cause major changes in vegetation structure and function over large fractions of the global land surface. Seven global vegetation models are used to ...
    • The Carbon Savings and Health Co-Benefits from the Introduction of Mass Rapid Transit System in Greater Kuala Lumpur, Malaysia 

      Kwan, SC; Tainio, Marko Kalevi; Woodcock, James David; Sutan, R; Hisham, Hashim J
    • Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARgamma-defective (P465L) mice 

      Gotz, Alexander A; Vidal-Puig, Antonio; Rodel, Heiko G; Hrabe, de Angelis Martin; Stoeger, Tobias (2011-09-20)
      Abstract Background The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ...
    • Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype 

      Chaiyadet, Sujittra; Sotillo, Javier; Smout, Michael; Cantacessi, Cinzia; Jones, Malcolm K; Johnson, Michael S; Turnbull, Lynne et al. (Oxford University Press, 2015-05-17)
      Background.  Throughout Asia there is an unprecedented link between cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple processes including chronic inflammation and secretion of parasite ...
    • CARD9 negatively regulates NLRP3-induced IL-1β production upon Salmonella infection of macrophages 

      Pereira, Milton; Tourlomousis, Panagiotis; Wright, John Alexander; Monie, Tom; Bryant, Clare Elizabeth (Nature Publishing Group, 2016-09-27)
      Interleukin 1b (IL-1b) is a pro-inflammatory cytokine required for host control of bacterial infections. Its production must be tightly regulated to prevent excessive inflammation. Here we identify a surprising negative ...
    • Cardiac action of the first G protein biased small molecule apelin agonist. 

      Read, C; Fitzpatrick, CM; Yang, P; Kuc, RE; Maguire, Janet Julie; Glen, Robert Charles; Foster, RE et al. (Elsevier, 2016-09-15)
      Apelin peptide analogues displaying bias towards G protein signalling pathways have beneficial cardiovascular actions compared with the native peptide in humans $\textit{in vivo}$. Our aim was to determine whether small ...
    • Cardiac Alpha-V Beta-3 Integrin Expression Following Acute Myocardial Infarction in Humans 

      Jenkins, William SA; Vesey, Alex T; Stirrat, Colin; Connell, Martin; Lucatelli, Christophe; Neale, Anoushka; Moles, Catriona et al. (British Medical Journal Publishing Group, 2016)
      $\textbf{Objective}$ Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The α$_{v}$β$_{3}$ integrin receptor is a key mediator and determinant of cardiac repair. ...
    • Cardiac autonomic dysfunction is associated with high risk albumin: creatinine ratio in young adolescents with type 1 diabetes in AdDIT (Adolescent Type 1 Diabetes Cardio-Renal Interventional Trial) 

      Cho, Yoon Hi; Craig, Maria E; Davis, Elizabeth A; Cotterill, Andrew; Couper, Jennifer J; Cameron, Fergus J; Benitez-Aguirre, Paul Z et al. (American Diabetes Association, 2015-01-08)
      Objective: To examine the association between cardiac autonomic dysfunction and high albumin:creatinine ratio (ACR) in adolescents with type 1 diabetes. Research Design and Methods: Adolescents recruited as part of a ...
    • Cardiac disease and arrhythmogenesis: lessons from mouse studies 

      Choy, Lois; Yeo, Jie Ming; Tse, Vivian; Chan, Shing Po; Tse, Gary (Elsevier, 2016-05-14)
      The mouse is the second mammalian species, after the human, in which substantial amount of the genomic information has been analyzed. With advances in transgenic technology, mutagenesis is now much easier to carry out in ...
    • Cardiac involvement in hereditary myopathy with early respiratory failure 

      Steele, Hannah E; Harris, Elizabeth; Barresi, Rita; Marsh, Julie; Beattie, Anna; Bourke, John P; Straub, Volker et al. (Wolters Kluwer, 2016-08-10)
      Objective: To assess whether hereditary myopathy with early respiratory failure (HMERF) due to the c.951434T>C; (p.Cys31712Arg) TTN missense mutation also includes a cardiac phenotype. Method: Clinical cohort study of our ...
    • The cardiac torsion as a sensitive index of heart pathology: a model study 

      Cutrí, E; Serrani, Marta; Bagnoli, P; Fumero, R; Costantino, ML (Elsevier, 2015-10-31)
      The torsional behaviour of the heart (i.e. the mutual rotation of the cardiac base and apex) was proved to be sensitive to alterations of some cardiovascular parameters, i.e. preload, afterload and contractility. Moreover, ...
    • Cardiolipin dynamics and binding to conserved residues in the mitochondrial ADP/ATP carrier. 

      Duncan, Anna L; Ruprecht, Jonathan; Kunji, Edmund Richard; Robinson, Alan Jonathan (2018-05)
      Cardiolipin in eukaryotes is found in the mitochondrial inner membrane, where it interacts with membrane proteins and, although not essential, is necessary for the optimal activity of a number of proteins. One of them is ...
    • Cardiolipins bound to the mitochondrial ADP/ATP carrier in dodecylphosphocholine have disordered acyl chains and a non-native affinity 

      Kunji, Edmund Richard; Dehez, F; Schanda, P; Chipot, C
      Biophysical investigation of membrane proteins generally requires their extraction from native sources using detergents, a step that can lead, possibly irreversibly, to protein denaturation. The propensity of docecylphosphocholine ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β-/- atrial preparations. 

      Valli, Haseeb; Ahmad, Shiraz; Jiang, Anita Y; Smyth, Robert; Jeevaratnam, Kamalan; Matthews, Hugh Richard; Huang, Christopher Li-Hur (Elsevier, 2018-01)
      Introduction Recent studies reported that energetically deficient murine Pgc-1β-/- hearts replicate age-dependent atrial arrhythmic phenotypes associated with their corresponding clinical conditions, implicating action ...
    • Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase. 

      Frankenreiter, Sandra; Groneberg, Dieter; Kuret, Anna; Krieg, Thomas; Ruth, Peter; Friebe, Andreas; Lukowski, Robert (2018-05)
      Aims: It has been suggested that the nitric oxide-sensitive guanylyl cyclase (NO-GC)/cGMP-dependent signaling pathway affords protection against cardiac damage during acute myocardial infarction (AMI). It is, however, not ...
    • Cardiorespiratory fitness levels and associations with physical activity and body composition in young South African adults from Soweto 

      Prioreschi, A.; Brage, S.; Westgate, K.; Norris, S. A; Micklesfield, L. K (2017-04-05)
      Abstract Background This observational study aims to describe fitness, and objectively measured physical activity levels and patterns in 409 young black South African adults ...
    • Cardiorespiratory fitness levels and associations with physical activity and body composition in young South African adults from Soweto 

      Prioreschi, A; Brage, Soren; Westgate, Kathryn Louise; Norris, SA; Michelsfield, LK (BioMed Central, 2017-04-05)
      $\textbf{Background:}$ This observational study aims to describe fitness, and objectively measured physical activity levels and patterns in 409 young black South African adults (aged 19–20 years) from Soweto, as well as ...