Now showing items 2382-2401 of 12429

    • CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study 

      Castellucci, Lea; Jamieson, Sarra E.; Miller, E. Nancy; Menezes, Eliane; Oliveira, Joyce; Magalhaes, Andrea; Guimaraes, Luiz Henrique et al. (2010-01-20)
      Abstract Background L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression ...
    • Cyanobacteria and eukaryotic algae use different chemical variants of vitamin B12 

      Helliwell, Katherine Emma; Lawrence, Andrew David; Holzer, Andre; Kudahl, Ulrich Johan; Sasso, Severin; Kräutler, Bernhard; Scanlan, David John et al. (Elsevier (Cell Press), 2016-03-31)
      Eukaryotic microalgae and prokaryotic cyanobacteria are the major components of the phytoplankton. Determining factors that govern growth of these primary producers, and how they interact, is therefore essential to ...
    • Cyclic AMP Recruits a Discrete Intracellular Ca$^{2+}$ Store by Unmasking Hypersensitive IP$_{3}$ Receptors 

      Konieczny, V; Tovey, SC; Mataragka, S; Prole, DL; Taylor, CW (Elsevier, 2017-01-17)
      Inositol 1,4,5-trisphosphate (IP3) stimulates Ca$^{2+}$ release from the endoplasmic reticulum (ER), and the response is potentiated by 3',5'-cyclic AMP (cAMP). We investigated this interaction in HEK293 cells using carbachol ...
    • Cycling in São Paulo, Brazil (1997-2012): Correlates, time trends and health consequences 

      Sá, TH; Duran, AC; Tainio, M; Monteiro, CA; Woodcock, J (Elsevier, 2016-12)
      The purpose of the study was to describe cyclists and cycling trips, and to explore correlates, time trends and health consequences of cycling in São Paulo, Brazil from 1997 to 2012. Cross-sectional analysis using repeated ...
    • Cycling Li-O2 Batteries via LiOH Formation and Decomposition 

      Liu, Tao; Leskes, Michal; Yu, Wanjing; Moore, Amy J.; Zhou, Lina; Bayley, Paul M.; Kim, Gunwoo et al. (AAAS, 2015-10-30)
      The rechargeable aprotic Li-air (O₂) battery is a promising potential technology for next generation energy storage, but its practical realization still faces many challenges. In contrast to the standard Li-O₂ cells, which ...
    • Cycling provision separated from motor traffic: a systematic review exploring whether stated preferences vary by gender and age 

      Aldred, Rachel; Elliott, Bridget; Woodcock, James; Goodman, Anna (Taylor & Francis, 2016-07-14)
      In this paper we represent a systematic review of stated preference studies examining the extent to which cycle infrastructure preferences vary by gender and by age. A search of online, English-language academic and policy ...
    • Cyclopropanation using flow-generated diazo compounds 

      Roda, Nuria M.; Tran, Duc N.; Battilocchio, Claudio; Labes, Ricardo; Ingham, Richard J.; Hawkins, Joel M.; Ley, Steven V. (RSC, 2015-01-17)
      We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions. This protocol was applied to a wide range of ...
    • Cyfieithu iaith y caethweision yn Uncle Tom’s Cabin a darluniadau o siaradwyr ail iaith mewn llenyddiaeth Gymraeg 

      Willis, David (University of Wales Press, 2016-11-01)
      Uncle Tom’s Cabin, Harriett Beecher Stowe’s influential anti-slavery novel, appeared in eight different Welsh-language versions (translations, abridgements and adaptations) between 1852 and 1854. This paper looks at the ...
    • Cynicism as a strategic virtue 

      Rose, A; Duschinsky, R; Macnaughton, J (Elsevier, 2017-02-18)
    • CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer. 

      Thompson, Deborah J.; O’Mara, Tracy A.; Glubb, Dylan M.; Painter, Jodie N.; Cheng, Timothy; Folkerd, Elizabeth; Doody, Deborah et al. (Bioscientifica, 2015-11-16)
      Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol concentrations. We analysed 2,937 SNPs in 6,608 endometrial cancer cases and 37,925 controls and report the ...
    • CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen 

      Abraham, Jean E.; Maranian, Mel J.; Driver, Kristy E.; Platte, Radka; Kalmyrzaev, Bolot; Baynes, Caroline; Luccarini, Craig et al. (2010-08-23)
      Abstract Introduction Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 ...
    • Cystic Fibrosis Foundation and European Cystic Fibrosis Society Consensus Recommendations for the Management of Nontuberculous Mycobacteria in Individuals with Cystic Fibrosis. 

      Floto, R. Andres; Olivier, Kenneth N.; Saiman, Lisa; Daley, Charles L.; Herrmann, Jean-Louis; Nick, Jerry A.; Noone, Peadar G. et al. (BMJ, 2015)
      Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause chronic pulmonary infection, particularly in individuals with pre-existing inflammatory lung disease such as cystic fibrosis (CF). ...
    • Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiers 

      Tyzack, Jonathan D.; Mussa, Hamse Y.; Williamson, Mark J.; Kirchmair, Johannes; Glen, Robert C. (Chemistry Central, 2014-05-27)
      Background: The prediction of sites and products of metabolism in xenobiotic compounds is key to the development of new chemical entities, where screening potential metabolites for toxicity or unwanted side-effects is of ...
    • Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program 

      Park, Hyun Jung; Li, Juan; Hannah, Rebecca; Biddie, Simon; Leal-Cervantes, Ana I.; Kirschner, Kristina; Santa Cruz, David Flores et al. (Wiley, 2015-12-23)
      Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in ...
    • Cytokinin and auxin display distinct but interconnected distribution and signaling profiles to stimulate cambial activity 

      Immanen, Juha; Nieminen, Kaisa; Smolander, Olli-Pekka; Kojima, Mikiko; Serra, Juan Alonso; Koskinen, Patrik; Zhang, Jing et al. (Elsevier (Cell Press), 2016-07-14)
      Despite the crucial roles of phytohormones in plant development, comparison of the exact distribution profiles of different hormones within plant meristems has thus far remained scarce. Vascular cambium, a wide lateral ...
    • Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development 

      Lin, Andrew C; Tan, Chin Lik; Lin, Chien-Ling; Strochlic, Laure; Huang, Yi-Shuian; Richter, Joel D; Holt, Christine E (2009-03-02)
      Abstract Background Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for ...
    • Cytoreductive Nephrectomy in the Tyrosine Kinase Inhibitor Era: A Question That May Never Be Answered 

      Stewart, GD; Aitchison, M; Bex, A; Larkin, J; Lawless, C; Méjean, A; Nathan, P et al. (Elsevier, 2016-01-01)
      Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting ...
    • Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies 

      Zabet, NR; Catoni, M; Prischi, F; Paszkowski, J
      Methylation of cytosine is an epigenetic mark involved in the regulation of transcription, usually associated with transcriptional repression. In mammals, methylated cytosines are found predominantly in CpGs but in plants ...
    • Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility 

      Flores, JV; Cordero-Espinoza, L; Oeztuerk-Winder, F; Andersson-Rolf, A; Selmi, T; Blanco, S; Tailor, J et al. (Elsevier, 2017-01-10)
      Loss-of-function mutations in the cytosine-5 RNA methylase NSUN2 cause neurodevelopmental disorders in humans, yet the underlying cellular processes leading to the symptoms that include microcephaly remain unclear. Here, ...
    • Cytosolic PrP Can Participate in Prion-Mediated Toxicity 

      Thackray, Alana; Zhang, Chang; Arndt, Tina; Bujdoso, Raymond (American Society for Microbiology, 2014-05-07)
      Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants ...