Now showing items 2382-2401 of 11903

    • Default mode hypoconnectivity underlies a sex-related autism spectrum 

      Ypma, Rolf J. F.; Moseley, Rachel L.; Holt, Rosemary J.; Rughooputh, Naresh; Floris, Dorothea L.; Chura, Lindsay R.; Spencer, Michael D. et al. (Elsevier, 2016)
      Background: Females and males differ significantly in the prevalence and presentation of autism spectrum conditions. One theory of this effect postulates that autistic traits lie on a sex-related continuum in the general ...
    • Default mode network connectivity during task execution 

      Vatansever, D.; Menon, D. K.; Manktelow, A. E.; Sahakian, B. J.; Stamatakis, E. A. (Elsevier, 2015-07-26)
      Initially described as task-induced deactivations during goal-directed paradigms of high attentional load, the unresolved functionality of default mode regions has long been assumed to interfere with task performance. ...
    • The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations 

      Yao, Nailin; Chang, Richard Shek-Kwan; Cheung, Charlton; Pang, Shirley; Lau, Kui Kai; Suckling, John; Rowe, James B. et al. (Wiley, 2014-07-01)
      Background: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. ...
    • Defect Formation beyond Kibble-Zurek Mechanism and Holography 

      Chesler, Paul M.; García-García, Antonio M.; Liu, Hong (APS, 2015-05-14)
      We study the dynamic after a smooth quench across a continuous transition from the disordered phase to the ordered phase. Based on scaling ideas, linear response, and the spectrum of unstable modes, we develop a theoretical ...
    • Defect state passivation at III-V oxide interfaces for complementary metal-oxide-semiconductor devices 

      Robertson, J.; Guo, Y.; Lin, L. (AIP Publishing, 2014)
      The paper describes the reasons for the greater difficulty in the passivation of interface defects of III-V semiconductors like GaAs. These include the more complex reconstructions of the starting surface which already ...
    • Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. 

      Tschurtschenthaler, M; Adolph, TE; Ashcroft, JW; Niederreiter, L; Bharti, R; Saveljeva, S; Bhattacharyya, J et al. (Rockefeller University Press, 2017-02-01)
      ATG16L1$^{T300A}$, a major risk polymorphism in Crohn's disease (CD), causes impaired autophagy, but it has remained unclear how this predisposes to CD. In this study, we report that mice with Atg16l1 deletion in intestinal ...
    • Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression 

      Randle, Suzanne J.; Nelson, David E.; Patel, Shachi; Laman, Heike (Wiley, 2015-06-23)
      During the final stages of erythropoiesis, lineage-restricted progenitors mature over three to five cell divisions culminating with withdrawal from the cell cycle and the loss of most organelles, including mitochondria ...
    • Defective leukocyte adhesion and chemotaxis contributes to combined immunodeficiency in humans with autosomal recessive MST1 deficiency 

      Dang, Tarana Singh; Willet, Joseph D. P.; Griffin, Helen R.; Morgan, Neil V.; O'Boyle, Graeme; Arkwright, Peter D.; Hughes, Stephen M. et al. (Springer, 2016-01-22)
      Purpose To investigate the clinical and functional aspects of MST1 (STK4) deficiency in a profoundly CD4-lymphopenic kindred with a novel homozygous nonsense mutation in STK4. Although recent studies have described the ...
    • Defects and disorder in metal organic frameworks 

      Cheetham, Tony; Bennett, Thomas Douglas; Coudert, François-Xavier; Goodwin, Andrew (Royal Society of Chemistry, 2015-12-21)
      Across the materials spectrum, it is widely known that the presence of both point and extended defects can have a dramatic impact on properties. Defects are however normally associated with disorder, and here we explore ...
    • Defects in III-Nitride Microdisk Cavities 

      Ren, C. X.; Puchtler, T. J.; Zhu, T.; Griffiths, J. T.; Oliver, R. A. (Institute of Physics, 2016)
      Nitride microcavities offer an exceptional platform for the investigation of light-matter interactions as well as the development of devices such as high efficiency light emitting diodes (LEDs) and low-threshold nanolasers. ...
    • Defects in the NC2 repressor affect both canonical and non-coding RNA polymerase II transcription initiation in yeast 

      Gómez-Navarro, Natalia; Jordán-Pla, Antonio; Estruch, Francisco; E. Pérez-Ortín, José (2016-03-03)
      Abstract Background The formation of the pre-initiation complex in eukaryotic genes is a key step in transcription initiation. The TATA-binding protein (TBP) is a universal ...
    • Defence Expenditure and Economic Growth: Evidence from India 

      Tiwari, Aviral Kumar; Tiwari, A. P. (Association of Cambridge Studies, 2010)
    • Defending China’s National Image and ‘Defensive Soft Power’: the Case of Hong Kong’s ‘Umbrella Revolution’ 

      Loh, Dylan (Springer, 2016-06-18)
      This study examines the pro-democracy protests of Hong Kong in 2014 and how the protests became sites for Beijing’s representations of Chinese national image(s). It argues that ‘defensive soft power’ can be used to understand ...
    • Defending truthmaker non-maximalism 

      Simpson, Matthew (Wiley on behalf of the Northern Institute of Philosophy, 2014-12-05)
      Jago (2012) argues that truthmaker non-maximalism, the view that some but not all truths require truthmakers, is vulnerable to a challenge from truths which ascribe knowledge of propositions about things which don't exist. ...
    • Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge 

      Sholukh, Anton M.; Watkins, Jennifer D.; Vyas, Hemant K.; Gupta, Sandeep; Lakhashe, Samir K.; Thorat, Swati; Zhou, Mingkui et al. (Elsevier, 2015-03-11)
      Although IgA is the most abundantly produced immunoglobulin in humans, its role in preventing HIV-1 acquisition, which occurs mostly via mucosal routes, remains unclear. In our passive mucosal immunizations of rhesus ...
    • Deficient methylation and formylation of mt-tRNA$^{Met}$ wobble cytosine in a patient carrying mutations in NSUN3 

      Van Haute, Lindsey; Dietmann, Sabine; Kremer, Laura; Hussain, Shobbir; Pearce, Sarah F.; Powell, Christopher A.; Rorbach, Joanna et al. (Nature Publishing Group, 2016-06-30)
      Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease. Here we identify the RNA target for the previously uncharacterized ...
    • Defining KIR and HLA class I Genotypes at Highest Resolution Using High-Throughput Sequencing 

      Norman, Paul J.; Hollenbach, Jill A.; Nemat-Gorgani, Neda; Marin, Wesley M.; Norberg, Steven J.; Ashouri, Elham; Jayaraman, Jyothi et al. (Elsevier (Cell Press), 2016)
      The physiological functions of natural killer (NK) cells in human immunity and reproduction depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIR) and their HLA class I ligands: HLA-A, -B ...
    • Defining Molecular Initiating Events in the Adverse Outcome Pathway Framework for Risk Assessment 

      Allen, Timothy E. H.; Goodman, Jonathan M.; Gutsell, Steve; Russell, Paul (American Chemical Society, 2014-10-29)
      Consumer and environmental safety decisions are based on exposure and hazard data, interpreted using risk assessment approaches. The adverse outcome pathway (AOP) conceptual framework has been presented as a logical sequence ...
    • Defining Niger Delta Soils – Are They Laterites? 

      Alayaki, Funmilayo; Al-Tabbaa, Abir; Ayotamuno, Josiah (IISTE, 2015)
      The ambiguity of the use of the term ‘laterite’ to generally classify tropical soils especially for engineering purposes needed to be addressed. An attempt was made to analyze the silica-sesquioxide ratio of some Niger Delta ...
    • Defining robustness protocols: a method to include and evaluate robustness in clinical plans 

      McGowan, S. E.; Albertini, F.; Thomas, S. J.; Lomax, A. J. (IOP Publishing, 2015)
      Aim: To define a site-specific robustness protocol to be used during the clinical plan evaluation process. Method: Plan robustness of 16 skull base IMPT plans to systematic range and random set-up errors have been ...