Now showing items 2865-2884 of 18169

• #### Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells ﻿

(Wiley, 2016-08-17)
Application of the CRISPR/Cas9 system to edit the genomes of human pluripotent stem cells (hPSCs) has the potential to revolutionize hPSC-based disease modeling, drug screening, and transplantation therapy. Here, we aim ...
• #### Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease ﻿

(Elsevier (Cell Press), 2017-01-05)
Inherited retinal disease is a common cause of visual impairment and represents a highly heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals with inherited retinal disease, who ...
• #### Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ ﻿

(Endocrine Society, 2016-08-15)
Context: Lower thyroid-stimulating hormone (TSH) screening cut-offs have doubled the ascertainment of congenital hypothyroidism (CH), particularly cases with a eutopically-located gland-in-situ (GIS). Although mutations ...
• #### A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task? ﻿

(Hindawi Publishing Corporation, 2016-06-02)
Background. National guidelines prompted the implementation of a designated two-week wait referral pathway to facilitate the early diagnosis of sarcomas, to improve treatment outcomes. Methods. Patients referred to the ...
• #### A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations ﻿

(Elsevier, 2017-06-08)
Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on ...
• #### Comprehensive Study of the CuF2 Conversion Reaction Mechanism in a Lithium Ion Battery ﻿

(American Chemical Society, 2014-06-11)
Conversion materials for lithium ion batteries have recently attracted considerable attention due to their exceptional specific capacities. Some metal fluorides, such as CuF2, are promising candidates for cathode materials ...
• #### Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. ﻿

(2011-07-29)
Abstract Background Structural studies are increasingly providing huge amounts of information on multi-protein assemblies. Although a complete understanding of cellular processes will be dependent on an explicit characterization ...
• #### Compressed Sensing Electron Tomography of Needle-Shaped Biological Specimens - Potential for Improved Reconstruction Fidelity with Reduced Dose ﻿

(Elsevier, 2015-10-30)
Electron tomography is an invaluable method for 3D cellular imaging. The technique is, however, limited by the specimen geometry, with a loss of resolution due to a restricted tilt range, an increase in specimen thickness ...
• #### Compressing Sets and Multisets of Sequences ﻿

(IEEE, 2015-02-12)
This paper describes lossless compression algorithms for multisets of sequences, taking advantage of the multiset’s unordered structure. Multisets are a generalization of sets, where members are allowed to occur multiple ...
• #### Compressive deformation and failure of CrAlN/Si3N4 nanocomposite coatings ﻿

(AIP Publishing, 2014-02-28)
The deformation and failure mechanisms of CrAlN/Si3N4 coatings containing grains a few nanometres in size have been compared with those of conventional CrN-based coatings. It is shown that the addition of amorphous Si3N4 ...
• #### Compressive plasticity of a La-based glass-crystal composite at cryogenic temperatures ﻿

(Elsevier, 2016-04-06)
The La55Al25Cu10Ni10–10 vol.% Ti glassy composites have excellent compressive strength and plasticity at room temperature (RT). At cryogenic temperature (77 K), neither the glassy matrix, nor the Ti particles undergo ...
• #### Compressive response of a 3D non-woven carbon-fibre composite ﻿

(Elsevier, 2018-04-01)
The compressive response of a three-dimensional (3D) non-interlaced composite comprising three orthogonal sets of carbon fibre tows within an epoxy matrix is analysed. First, the compressive response is measured in three ...
• #### Compressive Sensing Reconstruction for Video: an Adaptive Approach Based on Motion Estimation ﻿

(IEEE, 2016-03-09)
This paper focuses on the problem of causally reconstructing Compressive Sensing (CS) captured video. The state-of-art causal approaches usually assume the signal support is static or changing sufficiently slowly over time, ...

• #### Compulsive sexual behavior: Prefrontal and limbic volume and interactions. ﻿

(Wiley, 2017-03)
$\textit{Background:}$ Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study ...
• #### Compulsivity Across the Pathological Misuse of Drug and Non-Drug Rewards ﻿

(Frontiers, 2016-08-03)
Behavioral adaptation is required for the successful navigation of a constantly changing environment. Impairments in behavioral flexibility are commonly observed in psychiatric disorders including those of addiction. This ...
• #### Compulsivity Reveals a Novel Dissociation between Action and Confidence ﻿

(Elsevier, 2017-10-11)
Confidence and actions are normally tightly interwoven—if I am sure that it is going to rain, I will take an umbrella—therefore, it is difficult to understand their interplay. Stimulated by the ego-dystonic nature of ...
• #### Computation of Forced Premixed Flames Dynamics ﻿

(Taylor & Francis, 2016-04-14)
Bluff body stabilised turbulent premixed flames subject to inlet velocity oscillation over a wide range of forcing frequency and amplitude are simulated using a flamelet-based combustion model. Two sets of detailed chemical ...
• #### Computation of the Field in an Axial Gap, Trapped-Flux Type Superconducting Electric Machine ﻿

(IEEE, 2014-11-04)
The Bulk Superconductivity Group at the University of Cambridge is currently investigating the use of high temperature superconductors in wire and bulk form to increase the electrical and magnetic loading of an axial gap, ...
• #### A Computational and Experimental Compressor Design Project for Japanese and British High-School Students ﻿

(ASME, 2017-05-01)
This paper describes an innovative, three-day, turbomachinery research project for Japanese and British high-school students. The project is structured using modern teaching theories which encourage student curiosity and ...