Now showing items 2865-2884 of 11928

    • Diversity of transcripts and transcript processing forms in plastids of the dinoflagellate alga Karenia mikimotoi 

      Dorrell, Richard G.; Hinksman, George A.; Howe, Christopher J. (Springer, 2016-01-14)
      Plastids produce a vast diversity of transcripts. These include mature transcripts containing coding sequences, and their processing precursors, as well as transcripts that lack direct coding functions, such as antisense ...
    • Diversity of transposable elements and repeats in a 600 kb region of the fly Calliphora vicina 

      Negre, Bárbara; Simpson, Pat (2013-04-03)
      Abstract Background Transposable elements (TEs) are a very dynamic component of eukaryotic genomes with important implications (e.g., in evolution) and applications (e.g., as transgenic tools). They also represent a major ...
    • The diversity of Type II supernova versus the similarity in their progenitors 

      Valenti, S.; Howell, D. A.; Stritzinger, M. D.; Graham, M. L.; Hosseinzadeh, G.; Arcavi, I.; Bildsten, L. et al. (Oxford University Press, 2016-04-14)
      High-quality collections of Type II supernova (SN) light curves are scarce because they evolve for hundreds of days, making follow-up observations time consuming and often extending over multiple observing seasons. In light ...
    • Diversity-oriented synthesis as a tool for identifying new modulators of mitosis 

      Ibbeson, Brett M.; Laraia, Luca; Alza, Esther; O'Connor, Cornelius J.; Tan, Yaw Sing; Davies, Huw M. L.; McKenzie, Grahame et al. (NPG, 2014-01-17)
      The synthesis of diverse 3-dimensional libraries has become of paramount importance for obtaining better leads for drug discovery. Such libraries are predicted to fare better than traditional compound collections in ...
    • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis 

      Charalambous, Marika; Teixeira Da Rocha, Simao; Radford, Elizabeth Jane; Medina-Gomez, Gema; Curran, Scott; Pinnock, Scarlett B.; Ferrón, Sacri R. et al. (PNAS, 2014-10-27)
      Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and obesity, as well as progressive liver dysfunction. Recent animal studies have underscored the importance of hepatic growth hormone (GH) ...
    • DNA brick self-assembly with an off-lattice potential 

      Reinhardt, Aleks; Frenkel, Daan (Royal Society of Chemistry, 2016-06-07)
      We report Monte Carlo simulations of a simple off-lattice patchy-particle model for DNA ‘bricks’. We relate the parameters that characterise this model with the binding free energy of pairs of single-stranded DNA molecules. ...
    • DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential 

      Hänsel-Hertsch, R; Antonio, MD; Balasubramanian, S (Nature Publishing Group, 2017-02-22)
      Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress ...
    • A DNA methylation biomarker of alcohol consumption 

      Liu, C; Marioni, RE; Hedman, ÅK; Pfeiffer, L; Tsai, P-C; Reynolds, LM; Just, AC et al. (Nature Publishing Group, 2016-11-15)
      The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. ...
    • DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation 

      Farlik, M; Halbritter, F; Müller, F; Choudry, FA; Ebert, P; Klughammer, J; Farrow, S et al. (Elsevier, 2016-12-01)
      Hematopoietic stem cells give rise to all blood cells in a differentiation process that involves widespread epigenome remodeling. Here we present genome-wide reference maps of the associated DNA methylation dynamics. We ...
    • DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis 

      Yelina, Nataliya E.; Lambing, Christophe; Hardcastle, Thomas J.; Zhao, Xiaohui; Santos, Bruno; Henderson, Ian R. (Cold Spring Habour Laboratory Press, 2015-10-17)
      During meiosis, homologous chromosomes undergo crossover recombination, which is typically concentrated in narrow hot spots that are controlled by genetic and epigenetic information. Arabidopsis chromosomes are highly DNA ...
    • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases 

      Ligthart, S; Marzi, C; Aslibekyan, S; Mendelson, MM; Conneely, KN; Tanaka, T; Colicino, E et al. (BioMed Central, 2016-12-12)
      BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade ...
    • DNA sequence properties that predict susceptibility to epiallelic switching. 

      Catoni, M; Griffiths, J; Becker, C; Zabet, NR; Bayon, C; Dapp, M; Lieberman-Lazarovich, M et al. (Nature Publishing Group, 2017-03-01)
      Transgenerationally heritable epialleles are defined by the stable propagation of alternative transcriptional states through mitotic and meiotic cell cycles. Given that the propagation of DNA methylation at CpG sites, ...
    • DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair 

      Sibanda, BL; Chirgadze, DY; Ascher, DB; Blundell, TL (American Association for the Advancement of Science, 2017-02-03)
      DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-strand breaks that would otherwise lead to apoptosis or cancer. We have solved its ...
    • DNA-Tile Structures Induce Ionic Currents through Lipid Membranes 

      Göpfrich, Kerstin; Zettl, Thomas; Meijering, Anna E. C.; Hernandez-Ainsa, Silvia; Kocabey, Samet; Liedl, Tim; Keyser, Ulrich F. (ACS Publications, 2015-03-27)
      Self-assembled DNA nanostructures have been used to create man-made transmembrane channels in lipid bilayers. Here, we present a DNA-tile structure with a nominal subnanometer channel and cholesterol-tags for membrane ...
    • DnaA and the timing of chromosome replication in Escherichia coli as a function of growth rate 

      Grant, Matthew A. A.; Saggioro, Chiara; Ferrari, Ulisse; Bassetti, Bruno; Sclavi, Bianca; Cosentino Lagomarsino, Marco (2011-12-21)
      Abstract Background In Escherichia coli, overlapping rounds of DNA replication allow the bacteria to double in faster times than the time required to copy the genome. The precise timing of initiation of DNA replication is ...
    • DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias 

      Yang, Liubin; Rodriguez, Benjamin; Mayle, Allison; Park, Hyun Jung; Lin, Xueqiu; Luo, Min; Jeong, Mira et al. (Elsevier (Cell Press), 2016-06-13)
      De novo DNA METHYLTRANSFERASE (DNMT) 3A is among the most frequently mutated genes in hematologic malignancies. However, the mechanisms through which DNMT3A normally suppresses malignancy development are unknown. Here, we ...
    • Do adults with high functioning autism or Asperger syndrome differ in empathy and emotion recognition? 

      Montgomery, Charlotte B.; Allison, Carrie; Lai, Meng-Chuan; Cassidy, Sarah; Langdon, Peter E.; Baron-Cohen, Simon (Springer, 2016)
      The present study examined whether adults with high functioning autism (HFA) showed greater difficulties in (i) their self-reported ability to empathise with others and/or (ii) their ability to read mental states in others’ ...
    • Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research? 

      Hunter, Sally; Brayne, Carol (2017-01-26)
      Abstract Background Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor ...
    • Do birds have the capacity for fun? 

      Emery, Nathan J.; Clayton, Nicola S. (Elsevier, 2015-01-05)
      A crow carries a jar lid to the top of a sloping snowy rooftop in Russia. Sitting on the lid and sliding down the roof, you could think of it as surfing. It picks up the lid and repeats this behaviour again and again (Figure ...
    • Do circadian genes and ambient temperature affect substrate-borne signalling during Drosophila courtship? 

      Medina, Izarne; Casal, José; Fabre, Caroline C. G. (Company of Biologists, 2015-10-30)
      Courtship signals can be air-borne or substrate-borne. They convey distinct and species-specific information from one individual to its prospective partner. Here, we study the substrate-borne vibratory signals generated ...