Now showing items 2905-2924 of 9714

    • Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis 

      Luhavaya, Hanna; Dias, Marcio V. B.; Williams, Simon R.; Hong, Hui; de Oliveira, Luciana G.; Leadlay, Peter F. (Wiley, 2015-09-17)
      Tetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles ...
    • The Epic of Pabuji ki par in Performance 

      Wickett, Elizabeth (World Oral Literature Project, 2010-10-19)
      In the spectacular performance tradition of Pabuji ki par, duos known as bhopas and bhopis, members of an indigenous musician caste of Rajasthan, sing the epic of Pabuji to nomadic communities in honour of their patron ...
    • The EPIC-InterAct study: a study of the interplay between genetic and lifestyle behavioural factors on the risk of type 2 diabetes in European populations 

      Forouhi, Nita G.; Wareham, Nicholas J. (Springer, 2014-10-11)
      The rising prevalence of type 2 diabetes around the world and the global pattern of variation in risk between countries have been widely attributed to an interplay between rising rates of obesity and poor lifestyles and ...
    • Epidemiological impact and cost-effectiveness of universal vaccination with Bexsero® to reduce meningococcal group B disease in Germany 

      Christensen, H.; Irving, T.; Koch, J.; Trotter, C. L.; Ultsch, B.; Weidemann, F.; Wichmann, O. et al. (Elsevier, 2016)
      Bexsero, a new vaccine against serogroup B meningococcal disease (MenB), was licensed in Europe in January 2013. In Germany, Bexsero is recommended for persons at increased risk of invasive meningococcal disease, but not ...
    • Epidemiology and control of human schistosomiasis in Tanzania 

      Mazigo, Humphrey D.; Nuwaha, Fred; Kinung’hi, Safari M.; Morona, Domenica; de Moira, Angela Pinot; Wilson, Shona; Heukelbach, Jorg et al. (2012-11-28)
      Abstract In Tanzania, the first cases of schistosomiasis were reported in the early 19th century. Since then, various studies have reported prevalences of up to 100% in some areas. However, for many years, there have been ...
    • Epidemiology and interactions of Human Immunodeficiency Virus -- 1 and Schistosoma mansoni in sub-Saharan Africa 

      Mazigo, Humphrey D.; Nuwaha, Fred; Wilson, Shona; Kinung'hi, Safari M.; Morona, Domenica; Waihenya, Rebecca; Heukelbach, Jorg et al. (2013-01-24)
      Abstract Human Immunodeficiency Virus-1/AIDS and Schistosoma mansoni are widespread in sub-Saharan Africa and co-infection occurs commonly. Since the early 1990s, it has been suggested that the two infections may interact ...
    • Epidemiology of diabetes 

      Forouhi, Nita Gandhi; Wareham, Nicholas J. (Elsevier, 2014-10-22)
      The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million ...
    • The epidemiology of first episode psychosis in early intervention in psychosis services: findings from the Social Epidemiology of Psychoses in East Anglia [SEPEA] study 

      Kirkbride, James B.; Hameed, Yasir; Ankireddypalli, Gayatri; Ioannidis, Konstantinos; Crane, Carolyn M.; Nasir, Mukhtar; Kabacs, Nikolett et al. (American Psychiatric Association, 2016)
      $\textit{Objective:}$ Few studies have characterized the epidemiology of first episode psychoses in rural or urban settings since the introduction of Early Intervention Psychosis services. To address this, we conducted a ...
    • Epidermal Deletion of HIF-2α stimulates wound closure 

      Cowburn, Andrew S.; Crotty Alexander, Laura E.; Southwood, Mark; Nizet, Victor; Chilvers, Edwin R.; Johnson, Randall S. (NPG, 2013-10-31)
      Wound closure requires a complex series of micro-environmentally influenced events. A key aspect of wound closure is the migration of keratinocytes across the open wound. It has been found previously that the response to ...
    • An epidermis-driven mechanism positions and scales stem cell niches in plants 

      Gruel, Jérémy; Landrein, Benoit; Tarr, Paul; Schuster, Christoph; Refahi, Yassin; Sampathkumar, Arun; Hamant, Olivier et al. (American Association for the Advancement of Science, 2016-01-21)
      How molecular patterning scales to organ size is highly debated in developmental biology. We explore this question for the characteristic gene expression domains of the plant stem cell niche residing in the shoot apical ...
    • Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing 

      Rainbow, Daniel B.; Yang, Xin; Burren, Oliver; Pekalski, Marcin L.; Smyth, Deborah J.; Klarqvist, Marcus D. R.; Penkett, Christopher J. et al. (2015-08-18)
    • Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications 

      Choudry, Fizzah Aziz; Frontini, Mattia (Hindawi, 2015-11-22)
      Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic ...
    • Epigenetic memory in plants 

      Iwasaki, Mayumi; Paszkowski, Jerzy (EMBO Press, 2014-08-07)
      Epigenetics refers to heritable changes in patterns of gene expression that occur without alterations in DNA sequence. The epigenetic mechanisms involve covalent modifications of DNA and histones, which affect transcriptional ...
    • An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland 

      dos Santos, Camila O.; Dolzhenko, Egor; Hodges, Emily; Smith, Andrew D.; Hannon, Gregory J. (Elsevier, 2015-05-07)
      Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar structures for milk production. Anecdotal evidence from multiparous ...
    • Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia 

      Gallipoli, Paolo; Giotopoulos, George; Huntly, Brian J. P. (SAGE, 2015-04-27)
      Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells. With the exception of a few specific AML subtypes, ...
    • The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in Acute Myeloid Leukemia 

      Giotopoulos, G.; Chan, W.-I.; Horton, S. J.; Ruau, D.; Gallipoli, P.; Fowler, A.; Crawley, C. et al. (Nature Publishing Group, 2015-04-20)
      Growing evidence links abnormal epigenetic control to the development of hematological malignancies. Accordingly, inhibition of epigenetic regulators is emerging as a promising therapeutic strategy. The acetylation status ...
    • Epigenetic remodelling of brain, body and behaviour during phase change in locusts 

      Burrows, Malcolm; Rogers, Stephen M; Ott, Swidbert R (2011-07-26)
      Abstract The environment has a central role in shaping developmental trajectories and determining the phenotype so that animals are adapted to the specific conditions they encounter. Epigenetic mechanisms can have many ...
    • Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells 

      Tchasovnikarova, Iva A.; Timms, Richard T.; Matheson, Nicholas J.; Wals, Kim; Antrobus, Robin; Göttgens, Berthold; Dougan, Gordon et al. (AAAS, 2015-05-28)
      Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of heterochromatin. We took an analogous approach to identify genes ...
    • Epigenetics and metabolism in 2014: Metabolic programming—knowns, unknowns and possibilities 

      Ozanne, Susan E. (Nature Reviews Endocrinology 11, 67–68 (2015) doi: 10.1038/nrendo.2014.218, 2014-12-09)
      Studies published in 2014 have helped in our understanding of the epigenetic mechanisms by which suboptimal nutritional exposures during in utero development are transmitted to subsequent generations through both ...