Now showing items 1-20 of 30

    • Abnormal Brain Activation in Excoriation (Skin Picking) Disorder: Evidence from an Executive Planning fMRI Study 

      Odlaug, Brian L.; Hampshire, Adam; Chamberlain, Samuel R.; Grant, Jon E. (The Royal College of Psychiatrists, 2015)
      Background: Excoriation (Skin Picking) Disorder (SPD) is a relatively common psychiatric condition whose neurobiological basis is unknown. Aims: We sought to probe the function of fronto-striatal circuitry in SPD. ...
    • ADHD symptoms in non-treatment seeking young adults: relationship with other forms of impulsivity 

      Chamberlain, Samuel R.; Ioannidis, Konstantinos; Leppink, Eric W.; Niaz, Faiza; Redden, Sarah A.; Grant, Jon E. (Cambridge University Press, 2016-09-29)
      Attention-Deficit Hyperactivity Disorder (ADHD) has been associated with various manifestations of impulsivity in adults, including elevated rates of other impulsive disorders, substance use, questionnaire-based impulsivity ...
    • Altered cognitive response to serotonin challenge as a candidate endophenotype for obsessive-compulsive disorder 

      Lochner, Christine; Chamberlain, Samuel R.; Kidd, Martin; Fineberg, Naomi A.; Stein, Dan J. (Springer, 2015-12-09)
      RATIONALE: Obsessive-compulsive disorder (OCD) implicates dysfunction of orbitofrontal and insula-related circuitry and of the serotonin system. There is an on-going search in psychiatry for intermediate biological markers, ...
    • Anxiety, Gambling Activity, and Neurocognition: A Dimensional Approach to a Non-Treatment-Seeking Sample 

      Medeiros, Gustavo C.; Sampaio, Daniela G.; Leppink, Eric W.; Chamberlain, Samuel R.; Grant, Jon E. (Akadémiai Kiadó, 2016-07-01)
      $\textit{Background and aims:}$ Previous analyses have highlighted significant associations between gambling disorder (GD)/ subsyndromal GD and increased rates of anxiety symptoms and anxiety disorders relative to the ...
    • Are obsessive–compulsive symptoms impulsive, compulsive or both? 

      Chamberlain, Samuel R.; Leppink, Eric W.; Redden, Sarah A.; Grant, Jon E. (Elsevier, 2016-04-15)
      Background: The relationships between obsessive–compulsive symptoms and distinct forms of impulsivity and compulsivity are unclear. Such examination would be relevant in terms of how best to classify psychiatric disorders ...
    • Behavioural addiction—A rising tide? 

      Chamberlain, Samuel R.; Lochner, Christine; Stein, Dan J.; Goudriaan, Anna E.; van Holst, Ruth Janke; Zohar, Joseph; Grant, Jon E. (Elsevier, 2015-08-25)
      The term ‘addiction’ was traditionally used in relation to centrally active substances, such as cocaine, alcohol, or nicotine. Addiction is not a unitary construct but rather incorporates a number of features, such as ...
    • Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition 

      Bandelow, Borwin; Baldwin, David; Abelli, Marianna; Bolea-Alamanac, Blanca; Bourin, Michel; Chamberlain, Samuel R.; Cinosi, Eduardo et al. (Taylor & Francis, 2016-07-15)
      ${\bf Objective:}$ Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers ...
    • brain circuitry of compulsivity 

      van den Heuvel, Odile A.; van Wingen, Guido; Soriano-Mas, Carles; Alonso, Pino; Chamberlain, Samuel R.; Nakamae, Takashi; Denys, Damiaan et al. (Elsevier, 2015-12-11)
      Compulsivity is associated with alterations in the structure and the function of parallel and interacting brain circuits involved in emotional processing (involving both the reward and the fear circuits), cognitive control, ...
    • Cognitive flexibility correlates with gambling severity in young adults 

      Leppink, Eric W.; Redden, Sarah A.; Chamberlain, Samuel R.; Grant, Jon E. (Elsevier, 2016-06-16)
      Although gambling disorder (GD) is often characterized as a problem of impulsivity, compulsivity has recently been proposed as a potentially important feature of addictive disorders. The present analysis assessed the ...
    • COMT genotype, gambling activity, and cognition 

      Grant, Jon E.; Leppink, Eric W.; Redden, Sarah A.; Odlaug, Brian L.; Chamberlain, Samuel R. (Elsevier, 2015-05-09)
      Neuropsychological studies of adults with problem gambling indicate impairments across multiple cognitive domains. Catechol-O-methyltransferase (COMT) plays a unique role in the regulation of dopamine in the prefrontal ...
    • A Double-Blind, Placebo-Controlled Trial of N-Acetyl Cysteine in the Treatment of Excoriation Disorder 

      Grant, Jon E.; Chamberlain, Samuel R.; Redden, Sarah A.; Leppink, Eric W.; Odlaug, Brian L.; Kim, Suck Won (American Medical Association, 2016-03-23)
      Importance: Excoriation (skin-picking) disorder (SPD) is a disabling, under-recognized condition in which individuals repeatedly pick at their skin, leading to noticeable tissue damage. To date there has been no clearly ...
    • Expanding the definition of addiction: DSM-5 vs. ICD-11 

      Grant, Jon E.; Chamberlain, Samuel R. (Cambridge University Press, 2016-05-06)
      While considerable efforts have been made to understand the neurobiological basis of substance addiction, the potentially “addictive” qualities of repetitive behaviors, and whether such behaviors constitute “behavioral ...
    • Fractionating impulsivity: Commentary on “choice impulsivity” and “rapid-response impulsivity” articles by Hamilton and colleagues. 

      Chamberlain, Samuel R.; Fineberg, Naomi A. (American Psychological Association, 2015-04-01)
      Comments on the original articles "Rapid-response impulsivity: Definitions, measurement issues, and clinical implications" (see record 2015-14753-004) and "Choice impulsivity: Definitions, measurement issues, and clinical ...
    • Gambling disorder and its relationship with substance use disorders: Implications for nosological revisions and treatment. 

      Grant, Jon E.; Chamberlain, Samuel R. (Wiley, 2013-09-18)
      BACKGROUND: Gambling disorder, recognized by the DSM-5 as a behavioral addiction, affects .4-1.6% of adults worldwide, and is highly comorbid with other mental health disorders, particularly substance use disorders ...
    • Impact of ADHD symptoms on clinical and cognitive aspects of problem gambling 

      Chamberlain, Samuel R.; Derbyshire, Katherine; Leppinkc, Eric; Grant, Jon E. (Elsevier, 2014-10-23)
      Problem gambling is common across cultures, and has been conceptualized in terms of impulsivity. While elevated rates of attention deficit hyperactivity disorder (ADHD) have been observed in problem gamblers, the relationship ...
    • Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. 

      Chamberlain, Samuel R.; Odlaug, Brian L.; Derbyshire, Katie L.; Leppink, Eric W.; Grant, Jon E. (Elsevier, 2014-09-03)
      Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural ...
    • Long Term Deep Brain Stimulation Treatment for Obsessive-Compulsive Disorder 

      Grant, Jon E.; Odlaug, Brian L.; Chamberlain, Samuel R. (Physicians Postgraduate Press, Inc, 2016)
    • Neural and psychological underpinnings of gambling disorder: A review 

      Grant, Jon E.; Odlaug, Brian L.; Chamberlain, Samuel R. (Elsevier, 2015-10-21)
      Gambling disorder affects 0.4 to 1.6% of adults worldwide, and is highly comorbid with other mental health disorders. This article provides a concise primer on the neural and psychological underpinnings of gambling disorder ...
    • Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment Seeking Young Adults 

      Chamberlain, Samuel R.; Derbyshire, Katie L.; Leppink, Eric W.; Grant, Jon E. (American Academy of Psychiatry and the Law, 2016-06-01)
      Antisocial personality disorder (ASPD) is a relatively common problem, but the neuropsychological profile of affected individuals has seldom been studied outside of criminal justice recruitment settings. Non–treatment-seeking ...
    • Obesity and dissociable forms of impulsivity in young adults. 

      Chamberlain, Samuel R.; Derbyshire, Katherine L.; Leppink, Eric; Grant, Jon E. (CUP, 2015-02-25)
      Objective. Obesity is one of the leading causes of preventable morbidity and mortality, and young people are increasingly affected. The aim of this study was to examine relationships between obesity and dissociable forms ...