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  Impact of Alternative Splicing on the Human Proteome 

  Liu, Y; Gonzàlez-Porta, M; Santos, S; Brazma, A; Marioni, JC; Aebersold, R; Venkitaraman, Ashok RamakrishnanWickramasinghe, VO et al. (Elsevier, 2017-08-01)

  Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, ...
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  Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS 

  Narvaez, AJ; Ber, S; Crooks, A; Emery, A; Hardwick, B; Guarino Almeida, E; Huggins, DJPerera, DRoberts-Thomson, MAzzarelli, RobertaHood, FEPrior, IAWalker, DWBoyce, RBoyle, RGBarker, SPTorrance, CJMcKenzie, GJVenkitaraman, Ashok Ramakrishnan et al. (Elsevier, 2017-08-10)

  Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic ...
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  Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity 

  Turrell, FK; Kerr, EM; Gao, M; Thorpe, H; Doherty, Gary Joseph; Cridge, J; Shorthouse, DSpeed, ASamarajiwa, Shamith AnushaHall, BAGriffiths, MMartins, Carla et al. (Cold Spring Harbor Laboratory Press, 2017-08-08)

  Lung adenocarcinoma accounts for ∼40% of lung cancers, the leading cause of cancer-related death worldwide, and current therapies provide only limited survival benefit. Approximately half of lung adenocarcinomas harbor ...
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  Development of a Prognostic Model That Predicts Survival After Pancreaticoduodenectomy for Ampullary Cancer. 

  Feretis, Michail; Wang, T; Iype, S; Duckworth, A; Brais, R; Basu, Bristi; Jamieson, NHuguet, EBalakrishnan, AJah, APraseedom, RHarper, SLiau, Siong-Seng et al. (Wolters Kluwer Health, 2017-07-31)

  Objectives: The aims of this study were to i) identify independent predictors of survival following pancreaticoduodenectomy for ampullary cancer and ii) develop a prognostic model of survival. Methods: Data were analysed ...

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