Department of Biochemistry: Recent submissions
Now showing items 1-4 of 614
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The Contribution of APP gene dosage to the molecular phenotypes of Alzheimer's disease in human trisomy 21 neurons
(2019-07-19)Down syndrome is a condition caused by trisomy 21 and occurs in 1 out of 700 births. People with trisomy 21 are high risk for developing Alzheimer’s disease, a neurodegenerative disease that causes approximately 65% of ... -
Structural and biophysical analysis of Human DNA repair protein CtIP
(2019-10-19)The integrity of our genome is constantly threatened by endogenous and exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. ... -
Investigating mechanisms of genome folding by single-cell Hi-C
(2019-07-05)In recent years researchers have begun to reveal the hierarchy of mammalian DNA folding from the 10 nm fibre to the intact whole genome. One of the key approaches used is the single-cell Hi-C. My lab and I developed a ... -
Glucuronoxylan Acetylation Patterns and Site-specific Acetyltransferases
(2019-07-03)Plant biomass is the biggest source of carbon-based materials for several industries such as food, agriculture, textile, construction, and biofuels, among others. Cellulose and xylan are the two major components of plant ...
