Department of Pharmacology: Recent submissions
Now showing items 1-4 of 195
-
Investigating the molecular pharmacology of class A and B G protein-coupled receptors
G protein-coupled receptors (GPCRs) possess an inherent ability to bind to an extremely diverse range of ligands and activate multiple downstream signalling pathways. It is becomingly increasingly evident, however, that ... -
On the mechanisms of substrate translocation by the ABC transporter MsbA
(2022-02-26)Multidrug resistance (MDR) has been a significant problem for decades and limits the use of available chemotherapeutic drugs in treatments of bacterial infections and cancers. One of the key reasons for the development of ... -
Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry
Ca2+ is a ubiquitous intracellular messenger. It regulates a variety of cellular activities, ranging from muscle contraction, neuronal transmission, secretion and cell growth to apoptosis. Store-operated Ca2+ entry (SOCE) ...
