Theses - Pharmacology
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Recent Submissions
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
The alteration of intracellular cyclic adenosine monophosphate (cAMP) levels plays important regulatory roles in both physiological and pathological conditions, such as cancer. As the most aggressive form of brain tumour, ... -
Signalling to intracellular Ca2+ channels
Ryanodine receptors (RyR), expressed within the ER or plasma membrane (PM), may contribute to regulated insulin secretion from pancreatic β-cells. Amplification by RyR of the Ca$^{2+}$ signals evoked by voltage-gated ... -
Exploring the role of BCL11A in the oesophagus and mammary gland using in vivo lineage tracing and 3D organoid models.
In the pursuit of effective cancer therapy, extensive disease heterogeneity remains one of the largest problems facing researchers. NGS sequencing has helped to identify specific markers of disease to deconvolute some of ... -
Probing the protein homeostasis mechanisms in long-lived naked mole-rats
The naked mole-rat (NMR) is a fascinating animal which has unique biological features including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest-living rodent, showing negligible senescence ...
