Theses - Pharmacology
About this collection
Recent Submissions
-
Investigating the molecular pharmacology of class A and B G protein-coupled receptors
G protein-coupled receptors (GPCRs) possess an inherent ability to bind to an extremely diverse range of ligands and activate multiple downstream signalling pathways. It is becomingly increasingly evident, however, that ... -
On the mechanisms of substrate translocation by the ABC transporter MsbA
(2022-02-26)Multidrug resistance (MDR) has been a significant problem for decades and limits the use of available chemotherapeutic drugs in treatments of bacterial infections and cancers. One of the key reasons for the development of ... -
Stoichiometry of the interactions between endogenous Orai1 and STIM1 during store-operated Ca2+ entry
Ca2+ is a ubiquitous intracellular messenger. It regulates a variety of cellular activities, ranging from muscle contraction, neuronal transmission, secretion and cell growth to apoptosis. Store-operated Ca2+ entry (SOCE) ... -
Understanding the biochemical properties and physiological function of the protein syncollin
Syncollin is a 16-kDa protein that was originally isolated from the pancreatic zymogen granule. It is now known also to be expressed in the gut, the spleen and in neutrophils. The protein contains intramolecular disulphide ...
