Theses - Pharmacology
About this collection
Recent Submissions
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Investigating the function of the multidrug transporter ABCG2
ABCG2 is a polyspecific membrane transporter of the ATP-binding cassette (ABC) superfamily, which is responsible for the efflux of a wide array of structurally unrelated molecules from mammalian cells. Physiologically, the ... -
Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
Tandem-repeat proteins are a class of proteins ubiquitous in nature and exploited in recent years in biotechnological and pharmaceutical applications due to their favourable biophysical properties. One such repeat motif, ... -
A study of novel tools to measure and perturb Aurora Kinase A protein stability
From our early classes in biology, we have been taught that proteins are the ‘molecular machinery’ of the cell, and that they carry out the cellular functions within the cell. At a top-down level, the amount of proteins ... -
Inhibiting platelet scramblase activity
In both thrombosis and haemostasis, two distinct populations of activated platelets form, pro-aggregatory and pro-coagulant platelets. Pro-aggregatory platelets have active integrins and aggregate together via fibrinogen ...
