Theses - Pharmacology
About this collection
Recent Submissions
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
(2019-07-20)The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed ... -
Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
(2004-11-23)The sensation of pain is evoked when the body experiences noxious stimuli, and such stimuli are detected by specialised primary sensory neurones called nociceptors. Modulation of the sensitivity of these nociceptors occurs ... -
A study of protein-DNA interactions using atomic force microscopy and DNA origami
(2019-05-18)The development and application of genome editing tools has accelerated in recent years. However, their widespread application, especially in the medical field, is delayed for various issues with the safety of the tools ... -
High-resolution optical analyses of IP3-evoked Ca2+ signals
(2019-07-19)Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they ...
