Theses - Pharmacology
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Recent Submissions
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Development of a single-cell fluorescence-based sensor to investigate Myc protein stability
The transcription factor Myc is expressed in cells in response to pro-growth signals and drives expression of a plethora of genes that promote proliferation. This pleiotropic activity renders loss of Myc regulation highly ... -
Proton-sensing G protein-coupled receptor signalling in inflammation
Inflammation, the body’s response to tissue damage or infection, involves a number of cell types and is often associated with localised tissue acidosis. The resulting decrease in extracellular pH can exacerbate inflammation, ... -
Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
Event-driven pharmacology is a new paradigm in disease treatment for a wide range of diseases, including cancer, that have failed by traditional occupancy-driven pharmacology. One target that has been resistant to conventional ... -
Nucleic Acid Scaffold-dependent Proximity-mediated Enzyme Response (NASPER) - A Proof of Concept Study
Telomerase hTERT RNA is overexpressed in around 90% of all cancers but targeting it has been unsuccessful to date due to the inability of this approach to kill telomerase-expressing cells leading to the evolution of ...
