Theses - Pharmacology
About this collection
Recent Submissions
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A study of protein-DNA interactions using atomic force microscopy and DNA origami
(2019-05-18)The development and application of genome editing tools has accelerated in recent years. However, their widespread application, especially in the medical field, is delayed for various issues with the safety of the tools ... -
High-resolution optical analyses of IP3-evoked Ca2+ signals
(2019-07-19)Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they ... -
Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
(2019-03-23)The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. ... -
On the Structure and Function of Multidrug Efflux Pumps
(2019-05-18)Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor ...
