Theses - Pharmacology
About this collection
Recent Submissions
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Investigating the transcriptional regulation of BCL11A in Triple-negative Breast Cancer
(2019-10-10)Breast cancer is the most common type of cancer in women worldwide. It can be classified into several subtypes based on the histological expression of Estrogen, Progesterone and HER-2 receptors. The most aggressive subtype ... -
An interdisciplinary study of the mechanical and dynamic properties of α-solenoid repeat proteins
(2019-10-20)Tandem-repeat proteins differ from globular proteins, both in their biophysical characteristics and in how they interact with their respective partners, yet they comprise nearly one third of the human proteome and are ... -
Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
(2019-07-20)The inhibition of protein-protein interactions (PPIs) presents a major challenge to drug discovery. The properties of consensus-designed tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed ... -
Modulation of the sensitivity of nociceptive neurones by cannabinoids and SNSR
(2004-11-23)The sensation of pain is evoked when the body experiences noxious stimuli, and such stimuli are detected by specialised primary sensory neurones called nociceptors. Modulation of the sensitivity of these nociceptors occurs ...
