Theses - Pharmacology
About this collection
Recent Submissions
-
High-resolution optical analyses of IP3-evoked Ca2+ signals
(2019-07-19)Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they ... -
Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
(2019-03-23)The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. ... -
On the Structure and Function of Multidrug Efflux Pumps
(2019-05-18)Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor ... -
Ca2+ signalling between the endoplasmic reticulum and lysosomes
(2019-01-09)Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic ...
