Theses - Pharmacology
About this collection
Recent Submissions
-
THE USE OF CATALYTICALLY DEAD CAS9 TO IDENTFY KEY TRANSCRIPTION REGULATORS IN TRIPLE NEGATIVE BREAST CANCER
Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer cases. It tends to be aggressive, high-grade and poorly differentiated tumour with poor clinical outcome. Lack of expression of ... -
Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
The ubiquitin-proteasome system (UPS) maintains homeostatic levels of proteins in normal cells and controls the levels of oncogenes and tumour suppressors by tagging proteins with ubiquitin for proteasomal degradation. The ... -
Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
(2020-04-07)The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably ... -
Mechanisms of Peripheral Sensitization in Inflammatory Knee Pain
Arthritis affects millions of people and costs billions to the global economy with painful, inflamed joints being the major clinical symptoms. Knee joints are innervated by the distal ends of dorsal root ganglion (DRG) ...
