Theses - Pharmacology
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Recent Submissions
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
Type 2 diabetes mellitus (T2DM) is characterised by the hormonal imbalance of insulin and glucagon, leading to dysfunctional glucose homeostasis. Glucagon-like peptide 1 (GLP-1), which is an incretin hormone, activates the ... -
Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
Tandem-repeat (TR) domains occur in approximately one third of all proteins, yet these domains are less well understood compared with their globular counterparts. TR proteins act as molecular scaffolds that facilitate ... -
THE USE OF CATALYTICALLY DEAD CAS9 TO IDENTFY KEY TRANSCRIPTION REGULATORS IN TRIPLE NEGATIVE BREAST CANCER
Triple-negative breast cancer (TNBC) accounts for approximately 15-20% of all breast cancer cases. It tends to be aggressive, high-grade and poorly differentiated tumour with poor clinical outcome. Lack of expression of ... -
Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
The ubiquitin-proteasome system (UPS) maintains homeostatic levels of proteins in normal cells and controls the levels of oncogenes and tumour suppressors by tagging proteins with ubiquitin for proteasomal degradation. The ...
