Now showing items 5-8 of 20

    • High-resolution optical analyses of IP3-evoked Ca2+ signals 

      Mataragka, Stefania (2019-07-19)
      Ca2+ is a universal intracellular messenger that regulates many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they ...
    • Developing nanobodies to stabilise the tumour suppressor protein p16INK4a 

      Burbidge, Owen David (2019-03-23)
      The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. ...
    • On the Structure and Function of Multidrug Efflux Pumps 

      Neuberger, Arthur (2019-05-18)
      Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor ...
    • Ca2+ signalling between the endoplasmic reticulum and lysosomes 

      Atakpa, Peace (2019-01-09)
      Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic ...