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  • Establishment of mouse expanded potential stem cells 

    Gottgens, Berthold; Tanaka, Y; Wilkinson, A; Reik, W
    Mouse embryonic stem cells derived from the epiblast1 contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm2 ...
  • Myeloproliferative neoplasms – from origins to outcomes 

    Nangalia, J; Green, Anthony Richard
    Substantial progress has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago heralded a new age for patient care as a consequence ...
  • Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program 

    Loughran, Stephen John; Comoglio, F; Hamey, Fiona; Gottgens, Berthold; Hendrich, Brian; Green, Anthony Richard (Rockefeller University Press, 2017-10-02)
    Differentiation of lineage-committed cells from multipotent progenitors requires establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription ...
  • Novel epigenetic therapies in hematological malignancies: Current status and beyond 

    Gallipoli, Paolo; Huntly, Brian James
    Over the last decade transcriptional dysregulation and altered epigenetic programs have emerged as a hallmark in the majority of hematological cancers. Several epigenetic regulators are recurrently mutated in many hematological ...

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