Department of Haematology
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells Recent advances in single-cell technologies have permitted the investigation of heterogeneous cell populations at previously unattainable resolution. In this thesis single-cell approaches are applied to resolve the molecular ...
(2020-02-04)Abstract Deciphering pre-leukaemic dysregulation caused by mutant C/EBPα at the level of the single cell Moosa Rashid Qureshi C/EBPα is an ideal candidate to explore pre-leukaemic dysregulation of transcriptional networks ...
Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution (2020-05-16)Blood formation is coordinated by a set of functionally heterogeneous haematopoietic stem cell (HSC) compartments both in mouse and in human. However, how this diversity is regulated at the cellular and molecular level and ...