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  • Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data. 

    Lun, Aaron TL; Calero-Nieto, Fernando J; Haim-Vilmovsky, Liora; Göttgens, Berthold; Marioni, John Carlo (Cold Spring Harbor Laboratory Press, 2017-11)
    By pro ling the transcriptomes of individual cells, single-cell RNA sequencing provides unparalleled resolution to study cellular heterogeneity. However, this comes at the cost of high technical noise, including cell-spec ...
  • Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures. 

    Comoglio, Federico; Park, Hyun Jung; Schoenfelder, Stefan; Barozzi, Iros; Bode, Daniel; Fraser, Peter; Green, Anthony Richard (Cold Spring Harbor Laboratory Press, 2018-02-02)
    Thrombopoietin (TPO) is a critical cytokine regulating hematopoietic stem cell maintenance and differentiation into the megakaryocytic lineage. However, the transcriptional and chromatin dynamics elicited by TPO signaling ...
  • Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B 

    Zyryanova, AF; Weis, F; Faille, A; Abo Alard, A; Crespillo-Casado, A; Sekine, Y; Harding, Heather Parish et al. (2018-03-30)
    The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced phosphorylation of eukaryotic translation ...
  • The Role of Gata3 in Blood Stem Cell Emergence 

    Zaidan, Nada Mousa O (2018-07-31)
    The first definitive haematopoietic stem cells (HSCs) produced during embryonic development are generated from a specialised subset of endothelial cells known as haemogenic endothelium. Recently, it was reported that Gata3 ...

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