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  • Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma 

    Rui, L; Drennan, AC; Ceribelli, M; Zhu, F; Wright, GW; Huang, DW; Xiao, W et al. (National Academy of Sciences, 2016-11-15)
    Janus kinases (JAKs) classically signal by activating STAT transcription factors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41 (H3Y41-P). In diffuse large B-cell lymphomas ...
  • Acknowledging Errors: Advanced Molecular Replacement with Phaser 

    McCoy, Airlie J. (Springer, 2016)
    Molecular replacement is a method for solving the crystallographic phase problem using an atomic model for the target structure. State-of-the-art methods have moved the field significantly from when it was first envisaged ...
  • Transition states and cell fate decisions in epigenetic landscapes 

    Moris, Naomi; Pina, Cristina; Martinez Arias, Alfonso (Nature Publishing Group, 2016-09-12)
    Waddington’s epigenetic landscape is an abstract metaphor frequently used to represent the relationship between gene activity and cell fates during development. Over the past few years, it has become a useful framework for ...
  • Inherited Platelet Disorders: Towards DNA-based diagnosis 

    Lentaigne, Claire; Freson, Kathleen; Laffan, Michael A.; Turro, Ernest; Ouwehand, Willem H. (American Society of Hematology, 2016-04-19)
    Variations in platelet number, volume, and function are largely genetically controlled, and many loci associated with platelet traits have been identified by genome-wide association studies (GWASs). The genome also contains ...

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