Wellcome Sanger Institute: Recent submissions
Now showing items 1-4 of 93
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Somatic mutagenesis in humans with deficient DNA repair
The accumulation of mutations in normal cells causes the development of cancer and is implicated as a potential mechanism in the physiological process of ageing. In recent years our ability to interrogate the genome of ... -
Characterisation of Plasmodium parasite sexual commitment and development
Malaria is a devastating disease responsible for over 400,000 deaths each year. The disease is caused by a single-celled parasite of the genus Plasmodium, which establishes infection via a bite from an Anopheline mosquito. ... -
Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
The epigenetic landscape is regulated by a myriad of factors. This regulation ranges from functional compartmentalisation of genomic sequences into topologically associating domains, to chromosome looping, to short-range ... -
Somatic evolution in healthy and chronically inflamed colon and skin
The human body is made up of trillions of cells which cooperate to reproduce their genetic material. While all the cells are a part of a whole, each is also an individual and will selfishly give rise to a clonal expansion ...
