Wellcome Sanger Institute: Recent submissions
Now showing items 5-8 of 95
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Reconstructing Chromothriptic Chromosomes in Oesophageal Adenocarcinomas
The epigenetic landscape is regulated by a myriad of factors. This regulation ranges from functional compartmentalisation of genomic sequences into topologically associating domains, to chromosome looping, to short-range ... -
Somatic evolution in healthy and chronically inflamed colon and skin
The human body is made up of trillions of cells which cooperate to reproduce their genetic material. While all the cells are a part of a whole, each is also an individual and will selfishly give rise to a clonal expansion ... -
Human intestinal cells across space and time
(2022-01-17)Cells of the human intestinal tract undergo dynamic changes from development to adulthood and in response to environmental stimuli. Recent advances in high-throughput profiling of cells using transcriptomic approaches have ... -
Characterisation of Host- Parasite- Microbiota Interactions that Drive Hatching in Trichuris Species
(2022-04-30)Trichuris trichiura infections account for 400 million individuals infected across the tropics and subtropics, making it a key neglected tropical disease (NTD). Infection occurs upon ingestion of whipworm eggs that hatch ...