Now showing items 59-78 of 1005

    • Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma 

      Raiber, Eun-Ang; Beraldi, D; Martinez Cuesta, Sergio; McInroy, GR; Kingsbury, Z; Becq, J; James, T et al.
      Aberrant genetic and epigenetic variations drive malignant transformation and are hallmarks of cancer. Using PCR-free sample preparation we achieved the first in-depth whole genome (hydroxyl)-methylcytosine, single-base-resolution ...
    • Base-Mediated Cascade Rearrangements of Aryl-Substituted Diallyl Ethers 

      Reid, Jolene P; McAdam, Catherine A; Johnston, Adam JS; Grayson, Matthew; Goodman, Jonathan Michael; Cook, Matthew J (ACS, 2014-12-16)
      Two base mediated cascade rearrangement reactions of diallyl ethers were developed leading to selective [2,3]-Wittig-oxy-Cope and isomerization-Claisen rearrangements. Both diaryl and aryl-silyl substituted 1,3-substituted ...
    • Bayesian Inference of Accurate Population Sizes and FRET Efficiencies from Single Diffusing Biomolecules 

      Murphy, Rebecca R; Danezis, George; Horrocks, Mathew Harry; Jackson, Sophie Elizabeth; Klenerman, David (ACS, 2014-08-08)
      It is of significant biophysical interest to obtain accurate intramolecular distance information and population sizes from single-molecule Förster resonance energy transfer (smFRET) data obtained from biomolecules in ...
    • Benchmarking the Thermodynamic Analysis of Water Molecules Around a Model Beta Sheet 

      Huggins, David John (Wiley, 2012-03-27)
      Water molecules play a vital role in biological and engineered systems by controlling intermolecular interactions in the aqueous phase. Inhomogeneous fluid solvation theory provides a method to quantify solvent thermodynamics ...
    • Benzylammonium Heptanoate 

      Clarke, Stuart Matthew; Wood, Mary H (International Union of Crystallography, 2013-05-01)
      The title 1:1 stoichiometric salt, C7H10N+·C7H13O2-, is formed by proton transfer between heptanoic acid and benzylamine. This combination contrasts to the recently published 2:1 acid-amine adduct of cation, anion and ...
    • Benzylammonium heptanoate–heptanoic acid (1/1) 

      Wood, Mary Hannah; Clarke, Stuart Matthew (International Union of Crystallography, 2013-03-01)
      The title salt, C7H10N+·C7H13O2-·C7H14O2, is an unusual 2:1 stoichiometric combination of two carboxylic acid molecules and one amine. Although there are crystal structures of a number of 1:1 complexes reported in the ...
    • Benzylammonium hexanoate 

      Wood, Mary H; Clarke, Stuart Matthew (International Union of Crystallography, 2012-10-01)
      A binary mixture of benzylamine and hexanoic acid has been reacted to form the title salt, C7H10N+·C6H11O2-. This crystal has a 1:1 stoichiometry of acid- and amine-derived species which contrasts with other related species ...
    • Beyond rotamers: a generative, probabilistic model of side chains in proteins 

      Harder, Tim; Boomsma, Wouter; Paluszewski, Martin; Frellsen, Jes; Johansson, Kristoffer E; Hamelryck, Thomas (2010-06-05)
      Abstract Background Accurately covering the conformational space of amino acid side chains is essential for important applications such as protein design, docking and high resolution structure prediction. Today, the most ...
    • Bi-functional iron-only electrodes for efficient water splitting with enhanced stability through in-situ electrochemical regeneration 

      Martindale, Benjamin CM; Reisner, Erwin (Wiley, 2015-12-28)
      Scalable and robust electrocatalysts are required for the implementation of water splitting technologies as a globally applicable means of producing affordable renewable hydrogen. We demonstrate herein that iron-only ...
    • Bio-inspired Highly Scattering Networks via Polymer Phase Separation 

      Syurik, J; Jacucci, Giovanni; Onelli, Olimpia; Hölscher, H; Vignolini, Silvia (Wiley-Blackwell, 2018-01-01)
      A common strategy to optimize whiteness in living organisms consists in using three-dimensional random networks with dense and polydisperse scattering elements constituted by relatively low-refractive index materials. ...
    • Biocompatible and Sustainable Optical Strain Sensors for Large-Area Applications 

      Kamita, G; Frka-Petesic, Bruno; Allard, A; Dargaud, M; King, K; Dumanli, AG; Vignolini, Silvia (Wiley, 2016-12-01)
      By a simple two-step procedure, large photonic strain sensors using a biocompatible cellulose derivative are fabricated. Transient color shifts of the sensors are explained by a theoretical model that consideres the ...
    • Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel 

      Wu, Yuchao; Shah, Darshil Upendra; Liu, C; Yu, Ziyi; Liu, Ji; Ren, Xiaohe; Rowland, MJ et al.
      Inspired by biological systems, we report a supramolecular polymer–colloidal hydrogel (SPCH) composed of 98 wt % water that can be readily drawn into uniform ($\sim$6-μm thick) “supramolecular fibers” at room temperature. ...
    • Bioinspired Total Synthesis of Bussealin E. 

      Twigg, David G; Baldassarre, Leonardo; Frye, Elizabeth C; Galloway, Warren RJD; Spring, David Robert (2018-03-02)
      The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative ...
    • Biomimetic Supramolecular Polymer Networks Exhibiting both Toughness and Self-Recovery. 

      Liu, Ji; Tan, Cindy Soo Yun; Yu, Ziyi; Lan, Yang; Abell, Christopher; Scherman, Oren Alexander (2017-03)
      Biomimetic supramolecular dual networks: By mimicking the structure/function model of titin, integration of dynamic cucurbit[8]uril mediated host-guest interactions with a trace amount of covalent cross-linking leads to ...
    • Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles 

      Carvalho, SB; Freire, JM; Moleirinho, MG; Monteiro, F; Gaspar, D; Castanho, MARB; Carrondo, MJT et al. (American Chemical Society, 2016-10-19)
      Virus-like particles (VLPs) constitute a promising platform in vaccine development and targeted drug delivery. To date, most applications use simple nonenveloped VLPs as human papillomavirus or hepatitis B vaccines, even ...
    • Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates 

      Wright, Tuomas Pertti; Aprile, Francesco Antonio; Arosio, Paolo; Vendruscolo, Michele; Dobson, Christopher Martin; Knowles, Tuomas PJ (Royal Society of Chemistry, 2015-08-10)
      Molecular chaperones are key components of the arsenal of cellular defence mechanisms active against protein aggregation. In addition to their established role in assisting protein folding, there is increasing evidence ...
    • Bithiazole: An Intriguing Electron-Deficient Building for Plastic Electronic Applications. 

      Su, Haw-Lih; Sredojevic, Dusan N; Bronstein, Hugo Andres; Marks, Tobin J; Schroeder, Bob C; Al-Hashimi, Mohammed (2017-05)
    • Blockable Zn10 L15 Ion Channels through Subcomponent Self-Assembly. 

      Haynes, Cally Jo; Zhu, Jinbo; Chimerel, Catalin; Hernández-Ainsa, Silvia; Riddell, Imogen A; Ronson, Tanya Kimberley; Keyser, Ulrich Felix et al. (John Wiley & Sons Ltd., 2017-11-03)
      Metal-organic anion channels based on Zn10L15 pentagonal prisms have been prepared by subcomponent self-assembly. The insertion of these prisms into lipid membranes was investigated by ion-current and fluorescence measurements. ...
    • Boltzmann-conserving classical dynamics in quantum time-correlation functions: “Matsubara dynamics” 

      Hele, Timothy; Willatt, Michael J; Muolo, Andrea; Althorpe, Stuart Christian (AIP, 2015-04-02)
      We show that a single change in the derivation of the linearized semiclassical-initial value representation (LSC-IVR or “classical Wigner approximation”) results in a classical dynamics which conserves the quantum Boltzmann ...
    • Bovine Serum Albumin and Fibrinogen Adsorption at the 316L Stainless Steel/Aqueous Interface 

      Wood, Mary Hannah; Payagalage, Charanee G; Geue, Thomas
      The binding of bovine serum albumin (BSA) to a 316L stainless steel surface from a buffer solution has been characterised using neutron reflectometry (NR) and quartz crystal microbalance (QCM) measurements; coverage at all ...